Document Detail

Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants.
MedLine Citation:
PMID:  22419276     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Surfactant therapy is effective in improving the outcome of very preterm infants. Trials have studied a wide variety of surfactant preparations used either to prevent or treat respiratory distress syndrome (RDS). In animal models, prophylactic surfactant leads to more homogeneous distribution and less evidence of lung damage. However, administration requires intubation and treatment of infants who will not go on to develop RDS. This is of particular concern with the advent of improved approaches to providing continuous distending pressure, particularly in the form of nasal continuous positive airway pressure (CPAP).
OBJECTIVES: To compare the effect of prophylactic surfactant administration to surfactant treatment of established RDS in very preterm infants at risk of RDS.
SEARCH METHODS: We updated the search of the Cochrane Central Register of Controlled Trials (The Cochrane Library), MEDLINE, EMBASE, CINAHL, and clinical register in December 13, 2011.
SELECTION CRITERIA: Randomized and quasi-randomized controlled trials that compared the effects of prophylactic surfactant administration to surfactant treatment of established RDS in preterm infants at risk of RDS.
DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes were extracted from the reports of the clinical trials by the reviewers. Data analysis was done in accordance with the standards of the Cochrane Neonatal Review Group.
MAIN RESULTS: Eleven studies were identified that met inclusion criteria [nine without routine application of continuous positive air way pressure (CPAP) in the selective treatment group; two with routine application of CPAP in the selective treatment group]The meta-analysis of studies conducted prior to the routine application of CPAP demonstrated a decrease in the risk of air leak and neonatal mortality associated with prophylactic administration of surfactant. However, the analyses of studies that allowed for routine stabilization on CPAP demonstrated a decrease in the risk of chronic lung disease or death in infants stabilized on CPAP. When all studies were evaluated together, the benefits of prophylactic surfactant could no longer be demonstrated.
AUTHORS' CONCLUSIONS: Although the early trials of prophylactic surfactant administration to infants judged to be at risk of developing RDS compared to selective use of surfactant in infants with established RDS demonstrated a decreased risk of air leak and mortality, recent large trials that reflect current practice (including greater utilization of maternal steroids and routine post delivery stabilization on CPAP) do not support these differences and demonstrate less risk of chronic lung disease or death when using early stabilization on CPAP with selective surfactant administration to infants requiring intubation.
Maria Ximena Rojas-Reyes; Colin J Morley; Roger Soll
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Review     Date:  2012-03-14
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  3     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-15     Completed Date:  2012-06-07     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD000510     Citation Subset:  IM    
Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
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MeSH Terms
Combined Modality Therapy / methods
Continuous Positive Airway Pressure / methods*
Infant, Newborn
Infant, Premature
Pulmonary Surfactants / therapeutic use*
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome, Newborn / mortality,  prevention & control*
Reg. No./Substance:
0/Pulmonary Surfactants
Update Of:
Cochrane Database Syst Rev. 2001;(2):CD000510   [PMID:  11405966 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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