Document Detail

Prophylactic use of antimalarials during pregnancy.
MedLine Citation:
PMID:  22084457     Owner:  NLM     Status:  MEDLINE    
QUESTION: Some of my pregnant patients wish to travel to malaria-endemic regions. Are there medications that can be used safely during pregnancy for malaria prophylaxis?
ANSWER: Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus. Doxycycline and primaquine are not recommended during pregnancy.
Marie-Hélène Irvine; Adrienne Einarson; Pina Bozzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  57     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-04-10     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1279-81     Citation Subset:  IM    
Faculty of Pharmacy, University of Toronto, Ont.
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MeSH Terms
Antimalarials / adverse effects,  therapeutic use*
Atovaquone / adverse effects,  therapeutic use
Chloroquine / adverse effects,  therapeutic use
Doxycycline / adverse effects,  therapeutic use
Drug Combinations
Hydroxychloroquine / adverse effects,  therapeutic use
Malaria / prevention & control*
Mefloquine / adverse effects,  therapeutic use
Pregnancy Complications, Parasitic / prevention & control*
Primaquine / adverse effects,  therapeutic use
Proguanil / adverse effects,  therapeutic use
Reg. No./Substance:
0/Antimalarials; 0/Drug Combinations; 0/atovaquone, proguanil drug combination; 118-42-3/Hydroxychloroquine; 500-92-5/Proguanil; 53230-10-7/Mefloquine; 54-05-7/Chloroquine; 564-25-0/Doxycycline; 90-34-6/Primaquine; 94015-53-9/Atovaquone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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