| Prophylactic use of antimalarials during pregnancy. | |
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MedLine Citation:
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PMID: 22084457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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QUESTION: Some of my pregnant patients wish to travel to malaria-endemic regions. Are there medications that can be used safely during pregnancy for malaria prophylaxis? ANSWER: Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus. Doxycycline and primaquine are not recommended during pregnancy. |
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Authors:
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Marie-Hélène Irvine; Adrienne Einarson; Pina Bozzo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 57 ISSN: 1715-5258 ISO Abbreviation: Can Fam Physician Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-15 Completed Date: 2012-04-10 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 1279-81 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, University of Toronto, Ont. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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adverse effects,
therapeutic use* Atovaquone / adverse effects, therapeutic use Chemoprevention Chloroquine / adverse effects, therapeutic use Doxycycline / adverse effects, therapeutic use Drug Combinations Female Humans Hydroxychloroquine / adverse effects, therapeutic use Malaria / prevention & control* Mefloquine / adverse effects, therapeutic use Pregnancy Pregnancy Complications, Parasitic / prevention & control* Primaquine / adverse effects, therapeutic use Proguanil / adverse effects, therapeutic use Travel |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Drug Combinations; 0/atovaquone, proguanil drug combination; 118-42-3/Hydroxychloroquine; 500-92-5/Proguanil; 53230-10-7/Mefloquine; 54-05-7/Chloroquine; 564-25-0/Doxycycline; 90-34-6/Primaquine; 94015-53-9/Atovaquone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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