Document Detail

Prophylactic therapy with combined granisetron and dexamethasone for the prevention of post-operative vomiting in children.
MedLine Citation:
PMID:  10434165     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to compare the efficacy and safety of granisetron, a 5-hydroxytryptamine type 3 receptor antagonist, and dexamethasone and each drug alone for the prevention of post-operative vomiting by children, with no history of motion sickness and/or previous post-operative vomiting, undergoing general inhalational anaesthesia for surgery (inguinal hernia and phimosis). In a randomized, double-blind manner, 150 children, ASA physical status 1, aged 4-10 years, were assigned to receive granisetron 40 mg kg-1, dexamethasone 150 mg kg-1, or granisetron 40 mg kg-1 plus dexamethasone 150 mg kg-1 intravenously immediately after inhalation induction of anaesthesia (n = 50 of each). A complete response, defined as no emesis and no need for another rescue anti-emetic during the first 24 h after anaesthesia, was 86% with granisetron, 68% with dexamethasone and 98% with granisetron plus dexamethasone, respectively (P < 0.05; overall Fisher's exact probability test). No clinically serious adverse events were observed in any of the groups. In conclusion, prophylactic therapy with combined granisetron and dexamethasone was more effective than was each anti-emetic alone for the prevention of vomiting after paediatric surgery.
Y Fujii; Y Saitoh; H Tanaka; H Toyooka
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  16     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-17     Completed Date:  1999-09-17     Revised Date:  2014-04-03    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Inhalation
Antiemetics / administration & dosage*
Child, Preschool
Dexamethasone / administration & dosage*
Double-Blind Method
Drug Therapy, Combination
Granisetron / administration & dosage*
Hernia, Inguinal / surgery
Phimosis / surgery
Postoperative Nausea and Vomiting / prevention & control*
Serotonin Antagonists / administration & dosage*
Reg. No./Substance:
0/Antiemetics; 0/Serotonin Antagonists; 7S5I7G3JQL/Dexamethasone; WZG3J2MCOL/Granisetron
Retraction In:
Eur J Anaesthesiol. 2013 May;30(5):263-4   [PMID:  23571442 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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