Document Detail

Prophylactic and therapeutic uses of probiotics: a review.
MedLine Citation:
PMID:  11271697     Owner:  NLM     Status:  MEDLINE    
Probiotics, live microbial food supplements that beneficially affect the host by improving its intestinal microbial balance, are quickly gaining interest as functional foods in the current era of self-care and complementary medicine. Microbes have been used for years in food and alcoholic fermentations and relatively recently have undergone scientific scrutiny to examine their purported health benefits. Some of the claims for which research supports a beneficial effect of probiotic consumption include: improving intestinal tract health, enhancing the immune system, synthesizing and enhancing the bioavailability of nutrients, reducing symptoms of lactose intolerance, decreasing the prevalence of allergy in susceptible individuals, and reducing risk of certain cancers. The mechanisms by which probiotics exert their effects are largely unknown, but may involve modifying gut pH, antagonizing pathogens through production of antimicrobial and antibacterial compounds, competing for pathogen binding and receptor sites as well as for available nutrients and growth factors, stimulating immunomodulatory cells, and producing lactase. Selection criteria, efficacy, food and supplement sources and safety issues around probiotics are reviewed. Nutrition professionals can provide a tremendous service by helping clients overcome negative perceptions of all bacteria and, when appropriate, by developing individualized dietary plans to take advantage of the benefits probiotics may confer.
L Kopp-Hoolihan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  101     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-38; quiz 239-41     Citation Subset:  AIM; IM    
Dairy Council of California, 2222 Martin Ave #155, Irvine, CA 92612, USA.
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MeSH Terms
Biological Availability
Digestive System / microbiology
Digestive System Physiological Phenomena
Health Food / microbiology*
Hypersensitivity / prevention & control*,  therapy
Immune System / microbiology,  physiology
Lactose Intolerance / therapy*
Neoplasms / prevention & control*,  therapy
Probiotics / therapeutic use*
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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