Document Detail

Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  22836872     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of prophylactic theophylline for the prevention of severe renal dysfunction in post-asphyxiated term and post-term infants.
STUDY DESIGN: Systematic review and meta-analysis of randomized controlled trials (RCTs) comparing prophylactic theophylline vs placebo in term infants following perinatal asphyxia.
RESULT: Four RCTs involving 197 infants were included in the meta-analysis. Compared with placebo, prophylactic theophylline was associated with a significant reduction in the incidence of severe renal dysfunction (pooled relative risk) using fixed-effects model was 0.38 (95% confidence interval, 0.25 to 0.57; P<0.001).
CONCLUSION: The meta-analysis provides evidence that prophylactic theophylline significantly reduce the incidence of severe renal dysfunction. However, because of the lack of information on the long-term renal and neurodevelopmental outcome and measured theophylline levels with relation to adverse effects observed, prudence with the clinical use of prophylactic theophylline is required. Additionally, the included trials were prior to the era of therapeutic hypothermia and thus inference of renal benefit in an infant undergoing hypothermia therapy cannot be made.
H Al-Wassia; B Alshaikh; R Sauve
Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2012-07-26
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  33     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  2013-09-26     Revised Date:  2014-02-11    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
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MeSH Terms
Asphyxia Neonatorum / complications*
Glomerular Filtration Rate / drug effects
Infant, Newborn
Infant, Postmature*
Intensive Care, Neonatal / methods
Outcome Assessment (Health Care)
Randomized Controlled Trials as Topic
Renal Insufficiency / diagnosis,  etiology,  prevention & control*
Severity of Illness Index
Theophylline / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Vasodilator Agents; C137DTR5RG/Theophylline
Comment In:
J Perinatol. 2014 Jan;34(1):82-3   [PMID:  24374871 ]
J Perinatol. 2014 Jan;34(1):82   [PMID:  24374872 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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