Document Detail

Prophylactic methicillin for shunt operations: effects on incidence of shunt malfunction and infection.
MedLine Citation:
PMID:  7037325     Owner:  NLM     Status:  MEDLINE    
In a double-blind study, 74 children were randomly treated with prophylactic methicillin at the time of ventriculo-peritoneal shunting. There were 7 infections in the placebo group and 2 in the methicillin-treated group. There was no statistically significant difference in infection or overall malfunction rate between the two groups. The risk of shunt malfunction in the 2nd to 6th month after surgery was significantly greater in the placebo group (7 of 26 patients) than in the methicillin-treated group (1 of 26 patients). Delayed shunt malfunction may be prevented by a short course of perioperative antibiotics.
S J Haines; F Taylor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Child's brain     Volume:  9     ISSN:  0302-2803     ISO Abbreviation:  Childs Brain     Publication Date:  1982  
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505428     Medline TA:  Childs Brain     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  10-22     Citation Subset:  IM    
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MeSH Terms
Age Factors
Bacterial Infections / etiology,  prevention & control*
Cerebrospinal Fluid Shunts / adverse effects*
Child, Preschool
Clinical Trials as Topic
Double-Blind Method
Equipment Failure
Methicillin / therapeutic use*
Random Allocation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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