Document Detail

Prophylactic medication for unipolar depressive illness: the place of lithium carbonate in combination with antidepressant medication.
MedLine Citation:
PMID:  2138503     Owner:  NLM     Status:  MEDLINE    
A meta-analysis of the controlled clinical trials comparing the efficacy of combined lithium-imipramine therapy with each drug alone in the prevention of relapse in patients with unipolar depressive illness shows the combination to be superior to lithium alone (for any relapse, p less than 0.05; for specifically depressive relapse, p less than 0.025) and imipramine alone (for any relapse, p less than 0.025; for specifically depressive relapse, p less than 0.05). The issue of statistical power in studies of this kind is discussed. A single case of unipolar depressive illness is described, in which combined lithium-tranylcypromine therapy was superior to either drug alone. A combination of lithium and an antidepressant should be considered for any patient suffering from this condition who fails to remain well on either drug alone.
H R Kim; N J Delva; J S Lawson
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Meta-Analysis    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  35     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-01     Completed Date:  1990-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  107-14     Citation Subset:  IM    
Department of Psychiatry, Queen's University, Kingston, Ontario.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Clinical Trials as Topic
Depressive Disorder / drug therapy,  prevention & control*
Drug Therapy, Combination
Imipramine / therapeutic use
Lithium / therapeutic use*
Lithium Carbonate
Meta-Analysis as Topic
Middle Aged
Tranylcypromine / therapeutic use
Reg. No./Substance:
0/Antidepressive Agents; 155-09-9/Tranylcypromine; 50-49-7/Imipramine; 554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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