| Prophylactic lidocaine in the early phase of suspected myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 3895875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Four hundred two patients with suspected myocardial infarction seen within 6 hours of the onset of symptoms entered a double-blind randomized trial of lidocaine vs placebo. During the 1 hour after administration of the drug the incidence of ventricular fibrillation or sustained ventricular tachycardia among the 204 patients with acute myocardial infarction was low, 1.5%. Lidocaine, given in a 300 mg dose intramuscularly followed by 100 mg intravenously, did not prevent sustained ventricular tachycardia, although there was a significant reduction in the number of patients with warning arrhythmias between 15 and 45 minutes after the administration of lidocaine (p less than 0.05). The average plasma lidocaine level 10 minutes after administration for patients without a myocardial infarction was significantly higher than that for patients with an acute infarction. The mean plasma lidocaine level of patients on beta-blocking agents was no different from that in patients not on beta blocking agents. During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction. |
| | |
Authors:
|
H M Dunn; J M McComb; C D Kinney; N P Campbell; R G Shanks; G MacKenzie; A A Adgey |
Related Documents
:
|
1381305 - The prognostic significance of very low frequency ventricular ectopic activity in survi... 911585 - Effect of thiopentone on myocardial function. 6121935 - Comparative investigation of the effects of metoprolol, propranolol, practolol, and ver... 870245 - The effect of propranolol on microvascular injury in acute myocardial ischemia. 4044065 - The relation between left ventricular asynchrony, relaxation, outward wall motion and f... 23645915 - Influenza-like illness in acute myocardial infarction patients during the winter wave o... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American heart journal Volume: 110 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1985 Aug |
Date Detail:
|
Created Date: 1985-09-09 Completed Date: 1985-09-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 353-62 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arrhythmias, Cardiac / prevention & control Brain Diseases / chemically induced Cardiovascular Diseases / chemically induced Clinical Trials as Topic Creatine Kinase / blood Double-Blind Method Electrocardiography Female Humans Injections, Intramuscular Lidocaine / adverse effects, blood, therapeutic use* Male Middle Aged Myocardial Infarction / complications, drug therapy* Random Allocation Tachycardia / prevention & control Time Factors Ventricular Fibrillation / etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
|
137-58-6/Lidocaine; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neonatal sepsis.
Next Document: Assessment of the severity of valvular regurgitation by digital subtraction angiography compared to ...