| Prophylactic intravenous immunoglobulin replacement in high-risk burn patients. | |
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MedLine Citation:
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PMID: 2822723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty patients with extensive thermal injury were entered into a prospective randomized double-blind trial of prophylactic intravenous immunoglobulin administration. Ten patients received intravenous immunoglobulin and ten, albumin controls. No statistically significant difference was found between mortality rates, mortality rates from sepsis, the incidence of positive blood cultures, the positive quantitative wound biopsies, urine cultures, or positive intravenous line cultures. No significant improvement was noted in assays of neutrophil chemotactic index or intracellular kill, assays of lymphocyte function, or helper/suppressor ratio. We did, however, note significant improvement in the incidence of polymicrobial blood cultures, cytomegalovirus titers, and blood endotoxin concentration in treated patients. While the high incidence of inhalation injury (16 out of 20 patients) and, therefore, the disproportionately high mortality rate (40% overall) in the study group do not permit extension of these observations to the burn patient population at large, certain cautious recommendations may be made with regard to the use of intravenous immunoglobulin G in the management of burn patients. |
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Authors:
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A M Munster; K T Moran; J Thupari; M Allo; R A Winchurch |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 8 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1987 Sep-Oct |
Date Detail:
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Created Date: 1987-12-02 Completed Date: 1987-12-02 Revised Date: 2006-08-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 376-80 Citation Subset: IM |
Affiliation:
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Johns Hopkins University School of Medicine, Baltimore, MD. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Albumins / therapeutic use Burns / microbiology, mortality, therapy* Child Child, Preschool Cytomegalovirus / isolation & purification Double-Blind Method Endotoxins / blood Female Humans Immunoglobulin G / administration & dosage*, pharmacokinetics Infant Infusions, Intravenous Lymphocytes / immunology Male Middle Aged Neutrophils / immunology Prospective Studies Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Endotoxins; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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