Document Detail

Prophylactic implantable cardioverter defibrillator trials: MUSTT, MADIT, and beyond. Multicenter Unsustained Tachycardia Trial. Multicenter Automatic Defibrillator Implantation Trial.
MedLine Citation:
PMID:  11090794     Owner:  NLM     Status:  MEDLINE    
MUSTT and MADIT have clearly shown the survival benefit of an implantable cardioverter defibrillator (ICD) in patients with previous myocardial infarction, left ventricular ejection fraction < or = 0.40, and nonsustained ventricular tachycardia (VT), and who have had sustained VT induced at electrophysiology study. Progress in primary prevention of sudden cardiac death (SCD) depends on a concerted effort by clinicians to identify and appropriately treat MUSTT/MADIT-type patients; further research to more precisely define patient subgroups at risk for SCD and the willingness of industry to develop a lower priced ICD for prophylactic use are needed.
E N Prystowsky; S Nisam
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Publication Detail:
Type:  Comment; Comparative Study; Editorial; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-22     Completed Date:  2001-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1214-5, A5     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Death, Sudden, Cardiac / etiology,  prevention & control*
Defibrillators, Implantable*
Multicenter Studies as Topic*
Randomized Controlled Trials as Topic / methods*
Risk Factors
Tachycardia, Ventricular / complications,  therapy*
Ventricular Fibrillation / complications,  therapy*
Comment On:
Am J Cardiol. 1989 Apr 15;63(13):977-82 contd   [PMID:  2648794 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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