Document Detail


Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice.
MedLine Citation:
PMID:  17486687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Flaxseed (linseed, Linum usitatissimum, Linaceae) is widely used for its edible oil in many parts of the world. The present study investigates the radioprotective and antioxidative potential of flaxseed oil (FO). Swiss albino mice were administered FO orally once daily for 15 consecutive days, then exposed to a single dose of 5 Gy of gamma radiation. Lipid peroxide, reduced glutathione and total protein were estimated in the liver. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), acid and alkaline phosphatase estimations in serum were also carried out. Radiation-induced increases in the levels of lipid peroxidation (LPO), AST, ALT and acid phosphatase were significantly ameliorated by flaxseed oil pretreatment, and radiation-induced depletion in the level of glutathione (GSH) and alkaline phosphatase activities was significantly inhibited by flaxseed oil administration. The lifespan was increased in the flaxseed oil treated irradiated mice in comparison with their respective control mice, with survival data showing an LD(50/30) (lethal dose for 50% of animals after 30 days) of 7.1 and 10 Gy for control and FO treated irradiated mice, respectively, and produced a dose reduction factor for flaxseed oil (DRF) of 1.40. Radiation-induced deficits in body and organ weight were significantly reduced or prevented in flaxseed oil pretreated mice. The protection afforded by flaxseed oil may be attributed to the constituents of the oil, which include omega-3 essential fatty acids and phytoestrogenic lignans, which appear to play an important role in free radical scavenging and singlet oxygen quenching. The study does not rule out the possibility of a prophylactic potential of flaxseed oil against radiation-induced degenerative changes in liver.
Authors:
A L Bhatia; Avadhesh Sharma; Shikha Patni; Antim Lata Sharma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  21     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  852-9     Citation Subset:  IM    
Affiliation:
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302004, India. armbha@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Drug-Induced Liver Injury / prevention & control
Flax*
Gamma Rays
Linseed Oil / administration & dosage,  pharmacology*,  therapeutic use
Liver / drug effects*,  enzymology,  radiation effects
Male
Mice
Phytotherapy*
Radiation Dosage
Radiation Injuries, Experimental / prevention & control
Radiation-Protective Agents / administration & dosage,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Radiation-Protective Agents; 8001-26-1/Linseed Oil

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