Document Detail


Prophylactic ciprofloxacin drops after tympanostomy tube insertion.
MedLine Citation:
PMID:  14758376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effectiveness of prophylactic ciprofloxacin drops in decreasing the incidence of post-tympanostomy otorrhea, and the relation between middle ear content and post-tympanostomy otorrhea. METHODS: One hundred and fifty patients aged 3-14 years underwent tympanostomy and tube insertion at the Prince Rashid Ben Al-Hasan Hospital, Al-Husn, Jordan during the interval between February 2000 to January 2003. The patients were randomized into 3 groups: group 1 (control group) received no antibiotic drops, group 2 received a single dose of ciprofloxacin drops intraoperatively and group 3 received an intraoperative dose followed by 5-day postoperative course. RESULTS: Application of topical ciprofloxacin after tympanostomy tube insertion was associated with a significantly lower incidence of early post-tympanostomy otorrhea. The rate of otorrhea for the control group was 16.5% and the treatment groups were (group 1) 8.4%, (group 2) 8.2% and p=0.011. A single dose of antibiotics was effective when patient's middle ears were dry or had serous effusions. For those whose ears had mucoid or purulent content a 5-day course was indicated. CONCLUSION: Topical administration of a single dose of ototopical ciprofloxacin after surgery is an effective treatment for the prevention of early post-tympanostomy otorrhea, and a prolonged course (5 days) may be indicated for those whose ears had purulent or thick mucoid contents, and the content of middle ear are important in predicating postoperative otorrhea.
Authors:
Omer Nawasreh; Ibrahim A Al-Wedyan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Saudi medical journal     Volume:  25     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-10-05     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  38-40     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Prince Rashid Ben Al-Husn Hospital, Jordan. nawasreh1@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Antibiotic Prophylaxis*
Child
Child, Preschool
Ciprofloxacin / administration & dosage*
Female
Follow-Up Studies
Humans
Intraoperative Care
Jordan
Male
Middle Ear Ventilation / adverse effects,  methods*
Otitis Media with Effusion / diagnosis,  surgery*
Postoperative Care
Postoperative Complications / prevention & control
Probability
Reference Values
Risk Assessment
Solutions
Treatment Outcome
Chemical
Reg. No./Substance:
0/Solutions; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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