Document Detail

Prophylactic cerclage in the management of triplet pregnancies.
MedLine Citation:
PMID:  16157136     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine if prophylactic cerclage improves pregnancy outcome in women with triplet pregnancies without a history of cervical insufficiency. STUDY DESIGN: Triplet pregnancies with > or = 1 day of outpatient surveillance beginning before 32 weeks' gestation were identified from a database of women in the US who received outpatient preterm labor surveillance services between January 1990 and May 2004. Triplet pregnancies managed with prophylactic cerclage were compared with triplet pregnancies in which cerclage was not placed. Patients with a diagnosis of cervical insufficiency in a previous or in the index pregnancy were excluded from analysis. The primary outcome was incidence of preterm birth before 32 weeks. Groups were compared using Fisher exact test, and Student t test with 2-sided P values < .05 considered statistically significant. RESULTS: Three thousand two hundred seventy-eight triplet pregnancies met criteria for inclusion, of which 248 women (7.6%) received prophylactic cerclage. No significant differences were seen in mean gestational age at delivery, incidence of preterm birth before 32 weeks, birth weight, or neonatal days in the hospital. This study had 80% power to detect a 30% reduction in the primary outcome. CONCLUSION: Prophylactic cerclage did not result in improved pregnancy or neonatal outcomes in triplet pregnancies without a history of cervical insufficiency.
Andrei Rebarber; Ashley S Roman; Niki Istwan; Debbie Rhea; Gary Stanziano
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-6     Citation Subset:  AIM; IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, NYU School of Medicine, New York, NY, USA.
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MeSH Terms
Cerclage, Cervical*
Pregnancy Outcome*
Pregnancy, Multiple*
Premature Birth / epidemiology,  prevention & control
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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