Document Detail

Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide.
MedLine Citation:
PMID:  9793814     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the prophylactic administration of ondansetron plus droperidol, droperidol plus metoclopramide, and perphenazine to determine effects on postoperative nausea, vomiting, and sedation after laparoscopic cholecystectomy. DESIGN: Prospective, randomized, double-blind study. SETTING: University medical center. PATIENTS: 212 ASA physical status I and II adults presenting for laparoscopic cholecystectomy. INTERVENTIONS: Patients were randomly assigned to receive one of three prophylactic antiemetic drug combinations: ondansetron 4 mg plus droperidol 0.625 mg (Group OD), droperidol 0.625 mg plus metoclopramide 10 mg (Group DM), or perphenazine 5 mg (Group P). Study drugs were administered intravenously after induction of general anesthesia. MEASUREMENTS AND MAIN RESULTS: The groups were similar with respect to gender, age, weight, duration of surgery, numbers of patients receiving intraoperative atropine or ephedrine, number admitted overnight, and time to discharge home. Patients in Group P used lower total doses of opioids than did patients in Group OD. There were no significant differences in postoperative nausea, pain, or sedation scores, in numbers of patients requiring antiemetics (Group OD, 13 of 66; Group DM, 15 of 66; Group P, 14 of 68), or in numbers of patients vomiting, either in hospital or during the first postoperative day. CONCLUSIONS: These three drug regimens are equivalent for antiemetic prophylaxis before laparoscopic cholecystectomy.
R A Steinbrook; J L Gosnell; D Freiberger
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  10     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  IM    
Department of Anesthesia, Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Antiemetics / therapeutic use*
Cholecystectomy, Laparoscopic*
Double-Blind Method
Droperidol / administration & dosage,  therapeutic use
Metoclopramide / administration & dosage
Middle Aged
Nausea / prevention & control*
Ondansetron / therapeutic use
Perphenazine / therapeutic use
Postoperative Complications / prevention & control*
Prospective Studies
Vomiting / prevention & control*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 548-73-2/Droperidol; 58-39-9/Perphenazine; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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