| Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. | |
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MedLine Citation:
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PMID: 9793814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To compare the prophylactic administration of ondansetron plus droperidol, droperidol plus metoclopramide, and perphenazine to determine effects on postoperative nausea, vomiting, and sedation after laparoscopic cholecystectomy. DESIGN: Prospective, randomized, double-blind study. SETTING: University medical center. PATIENTS: 212 ASA physical status I and II adults presenting for laparoscopic cholecystectomy. INTERVENTIONS: Patients were randomly assigned to receive one of three prophylactic antiemetic drug combinations: ondansetron 4 mg plus droperidol 0.625 mg (Group OD), droperidol 0.625 mg plus metoclopramide 10 mg (Group DM), or perphenazine 5 mg (Group P). Study drugs were administered intravenously after induction of general anesthesia. MEASUREMENTS AND MAIN RESULTS: The groups were similar with respect to gender, age, weight, duration of surgery, numbers of patients receiving intraoperative atropine or ephedrine, number admitted overnight, and time to discharge home. Patients in Group P used lower total doses of opioids than did patients in Group OD. There were no significant differences in postoperative nausea, pain, or sedation scores, in numbers of patients requiring antiemetics (Group OD, 13 of 66; Group DM, 15 of 66; Group P, 14 of 68), or in numbers of patients vomiting, either in hospital or during the first postoperative day. CONCLUSIONS: These three drug regimens are equivalent for antiemetic prophylaxis before laparoscopic cholecystectomy. |
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Authors:
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R A Steinbrook; J L Gosnell; D Freiberger |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of clinical anesthesia Volume: 10 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-12-23 Completed Date: 1998-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 494-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesia, Brigham and Women's Hospital, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antiemetics / therapeutic use* Cholecystectomy, Laparoscopic* Double-Blind Method Droperidol / administration & dosage, therapeutic use Female Humans Male Metoclopramide / administration & dosage Middle Aged Nausea / prevention & control* Ondansetron / therapeutic use Perphenazine / therapeutic use Postoperative Complications / prevention & control* Prospective Studies Vomiting / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 364-62-5/Metoclopramide; 548-73-2/Droperidol; 58-39-9/Perphenazine; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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