Document Detail

Prophylactic antiemetic therapy with granisetron-dexamethasone combination in women undergoing breast surgery.
MedLine Citation:
PMID:  9809085     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dexamethasone decreases chemotherapy-induced emesis when added to an antiemetic regimen. This study was undertaken to evaluate the efficacy of granisetron-dexamethasone combination for the prevention of postoperative nausea and vomiting (PONV) in female patients undergoing general anaesthesia for breast surgery.
METHODS: In a randomized, double-blind manner, 135 ASA I patients, aged 40-65 years, were assigned to receive placebo (saline), granisetron 40 or granisetron 40 plus dexamethasone 8 mg i.v. (n = 45 of each) immediately before the induction of anaesthesia. A standard general anaesthetic technique and postoperative analgesia were used. The PONV and safety assessments were performed continuously during the first 3 h (0-3 h) and the next 21 h (3-24 h) after anaesthesia.
RESULTS: A complete response, defined as no PONV and no administration of rescue antiemetic medication, during 0-3 h after anaesthesia was 51%, 82% and 96% in patients who had received placebo, granisetron and granisetron-dexamethasone combination, respectively; the corresponding incidence during 3-24 h after anaesthesia was 56%, 84% and 98% (P < 0.05; overall Fisher's exact probability test). No clinically important adverse events were observed in any of the groups.
CONCLUSION: Prophylactic use of granisetron-dexamethasone combination is more effective than granisetron alone for the prevention of PONV after breast surgery.
Y Fujii; H Tanaka; H Toyooka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  42     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2013-04-25    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1038-42     Citation Subset:  IM    
Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.
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MeSH Terms
Antiemetics / administration & dosage*
Dexamethasone / administration & dosage*,  adverse effects
Double-Blind Method
Drug Therapy, Combination
Granisetron / administration & dosage*,  adverse effects
Middle Aged
Nausea / prevention & control*
Postoperative Complications / prevention & control*
Vomiting / prevention & control*
Reg. No./Substance:
0/Antiemetics; 109889-09-0/Granisetron; 50-02-2/Dexamethasone
Comment In:
Acta Anaesthesiol Scand. 1999 Apr;43(4):486-7   [PMID:  10225087 ]
Retraction In:
Acta Anaesthesiol Scand. 2013 Apr;57(4):538   [PMID:  23599940 ]

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