Document Detail


Prophylactic antiemetic therapy with a combination of granisetron and dexamethasone in patients undergoing middle ear surgery.
MedLine Citation:
PMID:  10193289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n = 40 in each group), immediately before induction of anaesthesia. A standardized general anaesthetic technique was used. A complete response, defined as no PONV and no need for another rescue antiemetic during the first 3 h after anaesthesia, was recorded in 83%, 50% and 98% of patients who had received granisetron, dexamethasone and granisetron-dexamethasone, respectively. The corresponding incidences during the next 21 h after anaesthesia were 80%, 55% and 98% (P < 0.05; overall Fisher's exact probability test). In summary, prophylactic use of combined granisetron and dexamethasone was more effective than each antiemetic alone for the prevention of PONV after middle ear surgery.
Authors:
Y Fujii; H Toyooka; H Tanaka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  81     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-04-20     Completed Date:  1999-04-20     Revised Date:  2013-04-26    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-6     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, General
Antiemetics / therapeutic use*
Dexamethasone / therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Ear, Middle / surgery*
Female
Granisetron / therapeutic use*
Humans
Male
Middle Aged
Postoperative Nausea and Vomiting / prevention & control*
Postoperative Period
Chemical
Reg. No./Substance:
0/Antiemetics; 109889-09-0/Granisetron; 50-02-2/Dexamethasone
Comments/Corrections
Retraction In:
Br J Anaesth. 2013 Apr;110(4):669   [PMID:  23508503 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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