Document Detail

Prophylactic antiemetic therapy with a combination of granisetron and dexamethasone in patients undergoing middle ear surgery.
MedLine Citation:
PMID:  10193289     Owner:  NLM     Status:  MEDLINE    
We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n = 40 in each group), immediately before induction of anaesthesia. A standardized general anaesthetic technique was used. A complete response, defined as no PONV and no need for another rescue antiemetic during the first 3 h after anaesthesia, was recorded in 83%, 50% and 98% of patients who had received granisetron, dexamethasone and granisetron-dexamethasone, respectively. The corresponding incidences during the next 21 h after anaesthesia were 80%, 55% and 98% (P < 0.05; overall Fisher's exact probability test). In summary, prophylactic use of combined granisetron and dexamethasone was more effective than each antiemetic alone for the prevention of PONV after middle ear surgery.
Y Fujii; H Toyooka; H Tanaka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  81     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-04-20     Completed Date:  1999-04-20     Revised Date:  2013-04-26    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-6     Citation Subset:  IM    
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
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MeSH Terms
Anesthesia, General
Antiemetics / therapeutic use*
Dexamethasone / therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Ear, Middle / surgery*
Granisetron / therapeutic use*
Middle Aged
Postoperative Nausea and Vomiting / prevention & control*
Postoperative Period
Reg. No./Substance:
0/Antiemetics; 109889-09-0/Granisetron; 50-02-2/Dexamethasone
Retraction In:
Br J Anaesth. 2013 Apr;110(4):669   [PMID:  23508503 ]

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