Document Detail

Prophylactic anticoagulation following acute myocardial infarction.
MedLine Citation:
PMID:  3513727     Owner:  NLM     Status:  MEDLINE    
Although several large trials have failed to demonstrate unequivocally that anticoagulation decreases mortality following myocardial infarction (MI), anticoagulation has been advocated to prevent embolic cerebrovascular accidents (CVAs). Since CVAs occur during hospitalization in only 1.5% to 3% of MIs, it is not justifiable to anticoagulate all patients after MI because the risk of anticoagulation exceeds the potential benefit. However, a group of patients who are at high risk of developing left ventricular thrombi (LVT) and CVA following MI can be identified. Thirty percent to 40% of patients with transmural anterior MI develop LVT, and early anticoagulation with heparin sodium prevents LVT formation and CVAs in this group. A two-dimensional echocardiogram before hospital discharge allows the identification of patients at risk for later embolization and helps determine the need for anticoagulation with warfarin sodium following hospitalization.
K Kaplan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  146     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-03-28     Completed Date:  1986-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  593-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiovascular Diseases / etiology*,  mortality,  prevention & control
Heart Diseases / prevention & control
Heparin / therapeutic use
Length of Stay
Myocardial Infarction / complications*
Thrombosis / prevention & control
Warfarin / therapeutic use
Reg. No./Substance:
81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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