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Prophylactic antibiotics for suction curettage in incomplete abortion.
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MedLine Citation:
PMID:  18475395     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: The purpose of this study was to investigate the efficacy of 200 mg of prophylactic doxycycline in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.Methods: A randomized, prospective, double-blinded study was carried out involving 300 women with an incomplete abortion who were given either placebo or 200 mg of doxycycline orally 30-60 min prior to curettage. A hematocrit, WBC count, pregnancy test, syphilis serology, Neisseria gonorrhoeae culture, and Micro Trak (monoclonal antibody test, Syba, San Jose, CA) for Chlamydia trachomatis were performed. The patients were scheduled for follow-up 2 weeks later. Antibiotic administration for any reason as well as the postoperative infection rate in these women was assessed.Results: Eleven women were excluded from analysis, leaving 289 evaluable. N. gonorrhoeae was isolated from 6 (2%) women and C. trachomatis from 8 (3%) women, and the syphilis serology was serofast in 4 (1%) women. Endometritis complicated the procedure in 4 women who received placebo and in 1 woman who received doxycycline (P = 0.22).Conclusion: Prophylactic doxycycline is not effective in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.
Authors:
K D Ramin; S M Ramin; P G Hemsell; B J Nobles; M C Heard; V B Johnson; D L Hemsell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  2     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Parkland Memorial Hospital 5323 Harry Hines Boulevard Dallas TX 75235-9032 USA.
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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 12 Month: 9 Year: 1994
Accepted Day: 29 Month: 12 Year: 1994
Print publication date: Year: 1995
Volume: 2 Issue: 5
First Page: 213 Last Page: 217
ID: 2364395
PubMed Id: 18475395
Publisher Item Identifier: S1064744995000044
DOI: 10.1155/S1064744995000044

Prophylactic Antibiotics for Suction Curettage in Incomplete Abortion
Kirk D. Ramin1
Susan M. Ramin1
Patricia G. Hemsell1
Brenda J. Nobles1
Molly C. Heard1
Vivian B. Johnson2
David L. Hemsell1
1Department of Obstetrics and GynecologyUniversity of Texas Southwestern Medical CenterParkland Memorial Hospital5323 Harry Hines BoulevardDallasTX75235-9032USA
2Department of PharmacyUniversity of Texas Southwestern Medical CenterParkland Memorial HospitalDallasTXUSA


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