| Prophylactic antibiotic treatment in acute necrotizing pancreatitis: results from a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 18609129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The effect of prophylactic antibiotic treatment on infection and survival of acute necrotizing pancreatitis (ANP) remains uncertain. The aim of this study was to assess the long-term efficacy of prophylactic antibiotic treatment for ANP. MATERIAL AND METHODS: Searches were carried out of electronic databases including Medline, EMBASE, the Cochrane Controlled Trials Register, the Science Citation Index, and PubMed (updated to December 2007), and manual bibliographical searches were also conducted. A meta-analysis of all randomized controlled trials (RCTs) comparing prophylactic antibiotic treatment with placebo or no treatment was performed. RESULTS: Eight RCTs including 540 patients were assessed. The outcomes included infected necrosis, death, non-pancreatic infection, surgical intervention, and length of hospital stay. Prophylactic antibiotic use leads to a significant reduction of infected necrosis (relative risk (RR) 0.69, 95% CI, 0.50-0.95; p=0.02), non-pancreatic infections (RR 0.66 95% CI, 0.48-0.91; p=0.01), and length of hospital stay (p=0.004) but was not associated with a statistically significant reduction in mortality (RR 0.76 95% CI, 0.50-1.18; p=0.22) and surgical intervention (RR 0.90 95% CI, 0.66-1.23; p=0.52). In a subgroup analysis, carbapenem was associated with a significant reduction in infected necrosis (p=0.009) and non-pancreatic infections (p=0.006), whereas other antibiotics were not. CONCLUSIONS: Prophylactic antibiotic treatment is associated with a significant reduction of pancreatic or peripancreatic infection, non-pancreatic infection, and length of hospital stay, but cannot prevent death and surgical intervention in acute necrotizing pancreatitis. |
| | |
Authors:
|
Tao Xu; Qingping Cai |
Related Documents
:
|
8648059 - Torulopsis glabrata-infected pancreatic pseudocysts. diagnosis and treatment. 6834949 - Complications of the treatment of malignant external otitis. 2123229 - Quantitative analysis of the bacterial findings in otitis media. 15513509 - Application of modified transmastoid approach methods to congenital atresia of the exte... 8829189 - Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. 2373599 - Risk factors for recurrent acute otitis media and respiratory infection in infancy. 22328669 - Hfq regulates biofilm gut blockage that facilitates flea-borne transmission of yersinia... 6877869 - Retarded development of schistosoma mansoni in immunosuppressed mice. 7141709 - Effect of estradiol on chlamydial genital infection of female guinea pigs. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 43 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-09-19 Completed Date: 2009-02-06 Revised Date: 2009-04-27 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
|
Languages: eng Pagination: 1249-58 Citation Subset: IM |
Affiliation:
|
Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
therapeutic use* Antibiotic Prophylaxis Bacterial Infections / complications, prevention & control* Female Humans Male Pancreatitis, Acute Necrotizing / drug therapy*, mortality* Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents |
| Comments/Corrections | |
Comment In:
|
Scand J Gastroenterol. 2009;44(5):637-8; author reply 639-40
[PMID:
18815941
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ASAT/ALAT ratio provides prognostic information independently of Child-Pugh class, gender and age in...
Next Document: Acute edematous and necrotic pancreatitis in a porcine model.