Document Detail

Prophylactic amnioinfusion in pregnancies complicated by oligohydramnios: a prospective study.
MedLine Citation:
PMID:  2014078     Owner:  NLM     Status:  MEDLINE    
Prophylactic amnioinfusion was assessed in term and post-dates pregnancies with decreased amniotic fluid volume. Subjects were randomly assigned to one of three groups: amnioinfusion with warmed saline solution, room-temperature saline, or control. Patients receiving prophylactic amnioinfusion had a significant decrease in both the frequency and severity of variable decelerations in the first stage of labor (P = .006) and in the average total number of variable decelerations in the first and second stages of labor (P = .01) compared with controls. There was no observed effect on newborn serum electrolyte levels with amnioinfusion, nor was there any apparent benefit of infusion of warmed saline compared with room-temperature saline. In contrast to premature gestations with oligohydramnios, prophylactic amnioinfusion was not associated with a significant improvement in mean umbilical arterial and venous pH or a significant decrease in cesarean delivery for fetal distress (P = .09). This is perhaps because the term fetus has an enhanced ability to tolerate recurrent episodes of heart rate decelerations without demonstrating the rapid metabolic changes seen in the premature fetus.
M P Nageotte; L Bertucci; C V Towers; D L Lagrew; H Modanlou
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  77     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-15     Completed Date:  1991-05-15     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  677-80     Citation Subset:  AIM; IM    
Women's Hospital Long Beach Memorial Medical Center, California.
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MeSH Terms
Fetal Growth Retardation / complications*
Gestational Age
Heart Rate, Fetal
Hot Temperature
Labor, Obstetric
Oligohydramnios / complications*,  therapy*
Pregnancy, Prolonged*
Prospective Studies
Sodium Chloride / administration & dosage*
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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