Document Detail


Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia.
MedLine Citation:
PMID:  8399865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty healthy patients were randomized to receive placebo, penicillin V (2 g), or amoxicillin (3 g) 1 hour before dental extraction was performed. Blood samples for microbiological investigation were collected before, during, and 10 minutes after surgery and were processed by lysis filtration under anaerobic conditions. There was no statistical difference among patients in the placebo group, the penicillin-V group, and the amoxicillin group in terms of incidence or magnitude of bacteremia due to viridans streptococci or anaerobic bacteria during extraction or 10 minutes after the procedure. The overall incidence rates of bacteremia after dental extraction were 95%, 90%, and 85%, respectively, for the three groups. For > 90% of 126 strains of viridans streptococci tested, the MICs of penicillin V and ampicillin were < or = 0.125 mg/L. The protective effect of prophylactically administered penicillins must be due to interference with crucial steps in the development of endocarditis (other than the transient bacteremia that occurs initially).
Authors:
G Hall; S A Hedström; A Heimdahl; C E Nord
Related Documents :
1960125 - Erythromycin and the treatment of coxiella burnetii pneumonia.
8399865 - Prophylactic administration of penicillins for endocarditis does not reduce the inciden...
11127175 - How effective are treatments other than antibiotics for acute sore throat?
11714065 - Once daily treatment with terbinafine 1% cream (lamisil) for one week is effective in t...
16908365 - Etanercept for the treatment of psoriasis in the elderly.
24018365 - The effectiveness of different treatment modalities for the rehabilitation of unilatera...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  17     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  188-94     Citation Subset:  IM    
Affiliation:
Department of Oral Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amoxicillin / therapeutic use*
Ampicillin Resistance
Bacteremia / etiology,  prevention & control*
Endocarditis, Bacterial / etiology,  prevention & control*
Female
Humans
Incidence
Male
Microbial Sensitivity Tests
Middle Aged
Penicillin Resistance
Penicillin V / therapeutic use*
Tooth Extraction / adverse effects*
Chemical
Reg. No./Substance:
26787-78-0/Amoxicillin; 87-08-1/Penicillin V
Comments/Corrections
Comment In:
Clin Infect Dis. 1993 Aug;17(2):195-7   [PMID:  8399866 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Flavobacterial sepsis in massively burned pediatric patients.
Next Document:  Characterization of the skeletal manifestations of the treponemal disease yaws as a population pheno...