Document Detail

Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia.
MedLine Citation:
PMID:  8399865     Owner:  NLM     Status:  MEDLINE    
Sixty healthy patients were randomized to receive placebo, penicillin V (2 g), or amoxicillin (3 g) 1 hour before dental extraction was performed. Blood samples for microbiological investigation were collected before, during, and 10 minutes after surgery and were processed by lysis filtration under anaerobic conditions. There was no statistical difference among patients in the placebo group, the penicillin-V group, and the amoxicillin group in terms of incidence or magnitude of bacteremia due to viridans streptococci or anaerobic bacteria during extraction or 10 minutes after the procedure. The overall incidence rates of bacteremia after dental extraction were 95%, 90%, and 85%, respectively, for the three groups. For > 90% of 126 strains of viridans streptococci tested, the MICs of penicillin V and ampicillin were < or = 0.125 mg/L. The protective effect of prophylactically administered penicillins must be due to interference with crucial steps in the development of endocarditis (other than the transient bacteremia that occurs initially).
G Hall; S A Hedström; A Heimdahl; C E Nord
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  17     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  188-94     Citation Subset:  IM    
Department of Oral Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Amoxicillin / therapeutic use*
Ampicillin Resistance
Bacteremia / etiology,  prevention & control*
Endocarditis, Bacterial / etiology,  prevention & control*
Microbial Sensitivity Tests
Middle Aged
Penicillin Resistance
Penicillin V / therapeutic use*
Tooth Extraction / adverse effects*
Reg. No./Substance:
26787-78-0/Amoxicillin; 87-08-1/Penicillin V
Comment In:
Clin Infect Dis. 1993 Aug;17(2):195-7   [PMID:  8399866 ]

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