Document Detail


Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes.
MedLine Citation:
PMID:  23334664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxidative stress is a key factor implicated in the development of diabetic neuropathy. This study evaluates the prophylactic and antinociceptive effects of the antioxidant coenzyme Q10 (CoQ10) on diabetes-induced neuropathic pain in a diabetic mouse model.
METHODS: Total 56 mice with type 1 diabetes induced by streptozotocin were used, 20 normal mice were used as control. Mechanical and thermal nociceptive behavioral assays were applied to evaluate diabetic neuropathic pain. Tissue lipid peroxidation, immunohistochemistry, reverse transcription, and polymerase chain reaction were used to evaluate the molecular mechanisms of CoQ10. Data are presented as mean ± SEM.
RESULTS: CoQ10 administration was associated with reduced loss of body weight compared with nontreated diabetic mice, without affecting blood glucose levels. Low dose and long-term administration of CoQ10 prevented the development of neuropathic pain. Treatment with CoQ10 produced a significant dose-dependent inhibition of mechanical allodynia and thermal hyperalgesia in diabetic mice. Dorsal root ganglia, sciatic nerve, and spinal cord tissues from diabetic mice demonstrated increased lipid peroxidation that was reduced by CoQ10 treatment. CoQ10 administration was also noted to reduce the proinflammatory factors in the peripheral and central nervous system.
CONCLUSIONS: The results of this study support the hypothesis that hyperglycemia induced neuronal oxidative damage and reactive inflammation may be pathogenic in diabetic neuropathic pain. CoQ10 may be protective by inhibiting oxidative stress and reducing inflammation by down-regulating proinflammatory factors. These results suggest that CoQ10 administration may represent a low-risk, high-reward strategy for preventing or treating diabetic neuropathy.
Authors:
Yan Ping Zhang; Ariel Eber; Yue Yuan; Zhe Yang; Yiliam Rodriguez; Roy C Levitt; Peter Takacs; Keith A Candiotti
Related Documents :
23173044 - Deletion of cdkal1 affects high-fat diet-induced fat accumulation and glucose-stimulate...
15235774 - Risk factor management in diabetic and non-diabetic patients with coronary heart diseas...
23374104 - At1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated...
23712834 - Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent.
15787604 - Atypical protein kinase c in insulin action and insulin resistance.
17227964 - Ketone bodies alter dinitrophenol-induced glucose uptake through ampk inhibition and ox...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  118     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-05-20     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  945-54     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Body Weight / drug effects
Diabetes Mellitus, Experimental / complications*
Diabetes Mellitus, Type 1 / complications*
Diabetic Neuropathies / complications,  drug therapy*
Disease Models, Animal
Dose-Response Relationship, Drug
Lipid Peroxidation
Male
Mice
Mice, Inbred C57BL
Oxidative Stress
Reverse Transcriptase Polymerase Chain Reaction / methods
Ubiquinone / analogs & derivatives*,  pharmacology
Vitamins / pharmacology*
Weight Loss / drug effects
Chemical
Reg. No./Substance:
0/Analgesics; 0/Vitamins; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of procalcitonin in the diagnosis of bone and joint infection: a systemic review and meta-an...
Next Document:  Pulmonary Shunt Is Independent of Decrease in Cardiac Output during Unsupported Spontaneous Breathin...