| Property and physiological role of biliary secretory IgA in rats. | |
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MedLine Citation:
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PMID: 6187905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secretory IgA (sIgA) and monomeric IgA (mIgA) were purified from normal rat bile, and their role in the gastrointestinal tract was investigated. Biliary sIgA has a molecular weight of approximately 400,000 daltons and a sedimentation constant of 11.7S. Thus, sIgA obtained from rat bile had physicochemical properties similar to those reported for sIgA in other secretions, and probably consists of L-chains, alpha-chains and secretory component. After in vitro incubation with trypsin or intestinal fluid, sIgA remained intact, whereas mIgA was hydrolyzed. Rats challenged repeatedly with dinitrophenylated bovine serum albumin (DNP-BSA) had specific IgA antibody against DNP in the bile and feces as measured by a radioimmunoassay using [3H]-DNP-lysine. Our results demonstrate a possibility that biliary sIgA, not mIgA, has an important role which inhibits the absorption of foreign antigen from intestine. |
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Authors:
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T Oku; A Akamatsu; N Hosoya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 28 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 643-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / physiology* Immunoglobulin A / isolation & purification, physiology* Immunoglobulin A, Secretory / immunology, isolation & purification, physiology* Intestinal Secretions / metabolism Male Rats Rats, Inbred Strains Secretory Component Trypsin / pharmacology Trypsin Inhibitors* gamma-Globulins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin A, Secretory; 0/Secretory Component; 0/Trypsin Inhibitors; 0/gamma-Globulins; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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