| Property editing of peptide nucleic acids (PNA): gem-dimethyl, cyanuryl and 8-aminoadenine PNAs. | |
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MedLine Citation:
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PMID: 18029564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We herein describe the introduction of gem-dimethyl substitution into the aminoethylglycyl backbone of PNA to impart steric constraint and pre-organise PNA for selective recognition of nucleic acids. Introduction of cyanuric acid and 8-aminoadenine as pyrimidine and purine analogs that can form base pairing from either face is also described to overcome the rotameric problems in PNA sidechain orientations and thereby enhance the statistical probability for base pairing. The UV-thermal melting studies of the derived triplexes with complementary DNA provide support for this rationale. |
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Authors:
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Krishna N Ganesh; A Gourishankar; Raman Vysabhattar; Pradnya Bokil |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 17-8 Citation Subset: IM |
Affiliation:
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National Chemical Laboratory, Pune, India. kn.ganesh@iiserpune.ac.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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analogs & derivatives*,
chemistry Base Pairing Hydrogen Bonding Nucleic Acid Denaturation Peptide Nucleic Acids / chemical synthesis, chemistry* Triazines / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Nucleic Acids; 0/Triazines; 108-80-5/cyanuric acid; 3868-33-5/8-aminoadenosine; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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