Document Detail


Properties of a new mouthrinse for patients receiving radiation therapy.
MedLine Citation:
PMID:  21180287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Patients receiving radiation therapy due to oral cancer develop complications such as hyposalivation, mucositis, oral infections, dental hypersensitivity and caries. Mouthrinses can alleviate some of these problems.
AIMS AND OBJECTIVES: To investigate the in vitro antimicrobial properties and cytotoxicity of an experimental mouthrinse.
METHODS: The mouthrinse contained 30% hexylene glycol (glycerine), 7% potassium nitrate and 0.025% sodium fluoride. The minimal inhibitory concentration (MIC) of these ingredients and the mixture was determined for C. albicans, S. aureus and S. mutans over 24 hours at different concentrations. The MICs of two commercial mouthrinses, Corsodyl and Plax, were also determined using the same organisms. All mouthrinses were then tested to determine the percentage kill over 1, 2, and 3 minutes.
RESULTS: The MICs for hexylene glycol were 10%, 30% and 10% for C. albicans, S. aureus and S. mutons respectively. Potassium nitrate and sodium fluoride had no antimicrobial effects. The MIC of Corsodyl was 0.016 mg/ml for all the test organisms. The MIC for Plax varied from 0.0002 mg/ml to 0.001 mg/ml. The kill rates for all mouthrinses were acceptable, with no statistical differences between them. The experimental mouthrinse was not toxic to human oesophageal SCC cells after 1 minute exposure. At the time of the experiment, the costs of a similar quantity of the experimental mouthrinse, Corsodyl and Plax were R5.24, R30.00 and R10.00 respectively.
CONCLUSIONS: The experimental mouthrinse was cost-effective and proved to have an antimicrobial effect and could be used safely to alleviate oral infections, desensitize teeth, improve oral hygiene and control dental caries in cancer patients after radiation therapy.
Authors:
M Patel; N N Ndlovu; C P Owen; R Veale
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging     Volume:  65     ISSN:  1029-4864     ISO Abbreviation:  SADJ     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-02-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9812497     Medline TA:  SADJ     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  410, 412-4     Citation Subset:  D    
Affiliation:
Department of Clinical Microbiology and Infectious Diseases, National Health Laboratory Services and Faculty of Health Sciences.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / economics,  pharmacology*,  toxicity
Benzoates / pharmacology
Candida albicans / drug effects
Carcinoma, Squamous Cell / pathology
Cariostatic Agents / pharmacology,  toxicity
Cell Adhesion / drug effects
Cell Line, Tumor
Chlorhexidine / analogs & derivatives,  pharmacology
Dentin Desensitizing Agents / pharmacology,  toxicity
Dose-Response Relationship, Drug
Esophageal Neoplasms / pathology
Glycols / pharmacology,  toxicity
Humans
Lubricants / pharmacology,  toxicity
Materials Testing
Microbial Sensitivity Tests
Mouthwashes / economics,  pharmacology*,  toxicity
Nitrates / pharmacology,  toxicity
Potassium Compounds / pharmacology,  toxicity
Radiotherapy* / adverse effects
Sodium Dodecyl Sulfate / pharmacology
Sodium Fluoride / pharmacology,  toxicity
Staphylococcus aureus / drug effects
Streptococcus mutans / drug effects
Time Factors
Triclosan / pharmacology
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Benzoates; 0/Cariostatic Agents; 0/Dentin Desensitizing Agents; 0/Glycols; 0/Lubricants; 0/Mouthwashes; 0/Nitrates; 0/Plax; 0/Potassium Compounds; 151-21-3/Sodium Dodecyl Sulfate; 3380-34-5/Triclosan; 55-56-1/Chlorhexidine; 7681-49-4/Sodium Fluoride; KEH0A3F75J/hexylene glycol; MOR84MUD8E/chlorhexidine gluconate; RU45X2JN0Z/potassium nitrate

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