| Properties of a new acid-buffering bioadhesive vaginal formulation (ACIDFORM). | |
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MedLine Citation:
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PMID: 11535216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vaginal prophylactic methodology may prevent heterosexual transmission of the HIV and other sexually transmitted disease-causing organisms as well as unplanned pregnancies. A new delivery system (ACIDFORM) was designed with acid-buffering, bioadhesive, and viscosity-retaining properties to (1) maintain the acidic vaginal milieu (the low pH inactivates many pathogens and spermatozoa), (2) form a protective layer over the vaginal/cervical epithelium (minimizing contact with pathogenic organisms), and (3) provide long-term vaginal retention. A Phase I clinical study with ACIDFORM provided initial information about its safety and showed the formation of a layer over the vaginal/cervical epithelium [1; Amaral et al., Contraception 1999;60:361-6]. To study the properties of the gel (without active ingredient) in more detail, ACIDFORM's acid-buffering, bioadhesive, viscosity-retaining, and spermicidal properties were compared in vitro to marketed formulations, and its long-term stability was assessed. ACIDFORM, either when titrated with NaOH or when mixed directly with semen, is highly acid buffering and much more effective than Aci-Jel, a commercial acid-buffering vaginal product. ACIDFORM adheres well to two model membranes (excised sheep vagina and cellophane) and is more bioadhesive than Conceptrol, Advantage S, Replens, Aci-Jel, and K-Y jelly. On dilution, ACIDFORM also retains its viscosity better than these marketed products. ACIDFORM is spermicidal and is stable for at least 2 years. These results suggest that ACIDFORM has advantages over presently marketed vaginal delivery systems. The gel may either be useful by itself as an antimicrobial contraceptive product or as a formulation vehicle for an active ingredient with antimicrobial and/or contraceptive properties. |
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Authors:
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S Garg; R A Anderson; C J Chany; D P Waller; X H Diao; K Vermani; L J Zaneveld |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Contraception Volume: 64 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-09-05 Completed Date: 2001-11-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Affiliation:
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Section of Ob/Gyn Research, Rush University, Rush Presbyterian St. Luke's Medical Center, Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins Chemistry, Pharmaceutical* Female HIV Infections / prevention & control* Humans Hydrogen-Ion Concentration / drug effects* Male Sexually Transmitted Diseases / prevention & control Spermatocidal Agents / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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2 PO1 AI37940-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/BufferGel; 0/Spermatocidal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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