Document Detail


Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?
MedLine Citation:
PMID:  7931255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Semicarbazide-sensitive amine oxidase (SSAO), occurs not only in vascular smooth muscle but also in other cell types (e.g. adipocytes, chondrocytes, odontoblasts), probably in the plasma membrane. Although certain aromatic biogenic amines (e.g. tryptamine, tyramine, beta-phenyl-ethylamine) may be endogenous substrates for SSAO in species such as the rat, the weak activity of SSAO in human tissues towards these amines makes this less likely in man. However SSAO in human and rat vascular homogenates readily converts the aliphatic biogenic amines methylamine and aminoacetone to formaldehyde and methylglyoxal, respectively. Also the xenobiotic aliphatic amine allylamine produces cardiovascular damage in experimental animals by a mechanism which involves its deamination by SSAO to acrolein. Further metabolism of these toxic aliphatic aldehydes may involve glutathione-dependent pathways. Thus, SSAO may be involved not only in the removal of physiologically-active endogenous/xenobiotic amines, but resulting metabolite (aldehyde/H2O2?) formation could also influence cellular function.
Authors:
G A Lyles
Related Documents :
158535 - Spontaneous activity and responses of reticular neurones in monoamine-depleted rats.
1747745 - Age effects on monoamine turnover of the rat substantia nigra.
2938235 - Influence of several aldehyde dehydrogenase and aldehyde reductase inhibitors on diamin...
10608515 - Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis ...
17520025 - Anthrax toxins induce shock in rats by depressed cardiac ventricular function.
2443355 - Argyrophil cells in the rat duodenum after gastrectomy.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neural transmission. Supplementum     Volume:  41     ISSN:  0303-6995     ISO Abbreviation:  J. Neural Transm. Suppl.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-23     Completed Date:  1994-11-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0425126     Medline TA:  J Neural Transm Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  387-96     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing)*
Amines / chemistry,  metabolism
Animals
Biogenic Amines / metabolism
Humans
Oxidoreductases Acting on CH-NH Group Donors / metabolism*,  physiology*
Rats
Semicarbazides / pharmacology*
Substrate Specificity
Tissue Distribution
Xenobiotics / metabolism
Chemical
Reg. No./Substance:
0/Amines; 0/Biogenic Amines; 0/Semicarbazides; 0/Xenobiotics; 57-56-7/carbamylhydrazine; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pinea...
Next Document:  Deamination of aliphatic amines by type B monoamine oxidase and semicarbazide-sensitive amine oxidas...