| Properties of the lymphatic cerebrospinal fluid transport system in the rat: impact of elevated intracranial pressure. | |
| | |
MedLine Citation:
|
PMID: 17587862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies suggested that a major portion of cerebrospinal fluid (CSF) is absorbed by extracranial lymphatics located in the olfactory turbinates. The objective of this study was to determine the impact of elevated intracranial pressure (ICP) on downstream cervical lymphatic pressures in the rat. Pressures were measured in the deep cervical lymph nodes using a servo-null micropressure system. A catheter was placed in a lateral ventricle and fluid was infused from a reservoir at defined ICPs. When Ringer's solution was infused, elevations of ICP from 10 to 50 cm H2O resulted on average in a reduction of diastolic cervical node pressures. In contrast, when a diluted plasma solution (80% plasma in Ringer's) was infused, downstream diastolic lymphatic pressures increased as ICP was elevated to 50 cm H2O. These data are consistent with the view that much of the CSF-derived water that convects into the lymphatics is absorbed into the ethmoidal or nodal blood vessels. This study supports the concept of fluid continuity between the subarachnoid space and extracranial lymphatics and suggests that this loss of CSF-derived water may act as a safety mechanism to reduce the volume load to the downstream lymphatic vessels. |
| | |
Authors:
|
Lena Koh; Gurjit Nagra; Miles Johnston |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-20 |
Journal Detail:
|
Title: Journal of vascular research Volume: 44 ISSN: 1423-0135 ISO Abbreviation: J. Vasc. Res. Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-08-29 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9206092 Medline TA: J Vasc Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 423-32 Citation Subset: IM |
Copyright Information:
|
Copyright 2007 S. Karger AG, Basel. |
Affiliation:
|
Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont., Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport Body Water / metabolism Cerebral Ventricles / metabolism Cerebrospinal Fluid / metabolism* Cerebrospinal Fluid Pressure Convection Ethmoid Bone / metabolism Evans Blue / pharmacokinetics Intracranial Hypertension / physiopathology* Iodine Radioisotopes / pharmacokinetics Isotonic Solutions / administration & dosage Lymph Nodes / metabolism Lymphatic System / physiopathology* Male Plasma Pressure Rats Rats, Sprague-Dawley Rheology Serum Albumin / pharmacokinetics Silicone Elastomers / pharmacokinetics Subarachnoid Space Turbinates / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Iodine Radioisotopes; 0/Isotonic Solutions; 0/Serum Albumin; 0/Silicone Elastomers; 314-13-6/Evans Blue; 8026-10-6/Ringer's solution |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of gap-junction-dependent arterial relaxation by ascorbic acid.
Next Document: Renoprotective effects of rosiglitazone in stroke-prone spontaneously hypertensive rats.