Document Detail

Properties of liposomal membranes composed of short-chain lecithins.
MedLine Citation:
PMID:  956148     Owner:  NLM     Status:  MEDLINE    
Permeability properties of multilamellar liposomes prepared from synthetic, saturated short-chain (C8, C10, C12) lecithins (3-sn-phosphatidyl choline) were studied. Dioctanoyllecithin, didecanoyllecithin, and dilauroyllecithin form "stable" bilayers which are practically impermeable to glucose when prepared with proportions of more than 1.2, 0.75, and 0.6 of cholesterol (molar ratio to phospholipid), respectively. Dioctanoyllecithin liposomes were rather leaky above 30 degrees, even when a proportion of 1.5 of cholesterol (molar ratio to lecithin) was incorporated. Judging from their sensitivities to temperature, Triton X-100, serum albumin, and other reagents, short-chain lecithin bilayers show characteristic properties, different from those of both saturated long-chain lecithins (dipalmitoyllecithin and dimyristoyllecithin) and lecithins having unsaturated fatty acid residues (egg lecithin and dioleoyllecithin).
T Kitagawa; K Inoue; S Nojima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biochemistry     Volume:  79     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2007-12-19    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1147-55     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents
Binding Sites
Biological Transport
Models, Biological
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Liposomes; 0/Lysophosphatidylcholines; 0/Phosphatidylcholines; 0/Phospholipids; 11024-24-1/Digitonin; 50-99-7/Glucose; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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