| Properties of antibiotic-loaded acrylic bone cements for use in cemented arthroplasties: a state-of-the-art review. | |
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MedLine Citation:
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PMID: 18823020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection of periprosthetic sites of total joint replacements has been widely reported. Although, by most accounts, the incidence of such events is low, the problem can prove to be expensive to remedy. In the case of cemented arthroplasties, a common management modality is the use of antibiotic-loaded acrylic bone cement (ALABC) as a prophylaxis or a therapeutic agent. Although there is a large literature on properties of ALABCs (on the order of 100 journal articles), a comprehensive review is lacking. The present contribution, whose objective is to fill this gap, is organized in four parts. Details of the background to and motivation for the work are given in the first part, explicative summaries of literature studies on the influence of various factors on an array of in vitro and in vivo properties of ALABCs are covered in the second part, issues and areas for future studies are presented in the third part, and the fourth part contains a summary of the most salient points made in the review. |
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Authors:
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Gladius Lewis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of biomedical materials research. Part B, Applied biomaterials Volume: 89 ISSN: 1552-4981 ISO Abbreviation: J. Biomed. Mater. Res. Part B Appl. Biomater. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-08 Completed Date: 2009-07-02 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101234238 Medline TA: J Biomed Mater Res B Appl Biomater Country: United States |
Other Details:
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Languages: eng Pagination: 558-74 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley Periodicals, Inc. |
Affiliation:
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Department of Mechanical Engineering, The University of Memphis, Memphis, Tennessee 38152, USA. glewis@memphis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / chemistry*, metabolism, pharmacology, therapeutic use* Arthroplasty* Biofilms / drug effects Humans Polymethyl Methacrylate / chemistry* Prosthesis-Related Infections / prevention & control Stress, Mechanical Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 9011-14-7/Polymethyl Methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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