Document Detail


Properties of N-Butyl Cyanoacrylate-iodized Oil Mixtures for Arterial Embolization: In Vitro and In Vivo Experiments.
MedLine Citation:
PMID:  22920981     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: To examine the properties of N-butyl cyanoacrylate (NBCA) and iodized oil (lipiodol [Lip]) in vitro and in vivo for safe and effective embolization.
MATERIALS AND METHODS: Viscosity, polymerization time, and diffusing capacity were evaluated according to the NBCA/Lip ratio in vitro. Additionally, the effect of the NBCA/Lip ratio on arterial embolization was evaluated in vivo; various ratios of NBCA/Lip were injected into the renal arteries of adult beagles, after which the embolization effect following transcatheter arterial embolization was quantitatively investigated histopathologically and using computed tomography (CT) volumetry.
RESULTS: The viscosity of NBCA/Lip increased, polymerization time was prolonged, and diffusing capacity increased as the NBCA density decreased. As the NBCA density decreased, embolic material was recognized in smaller diameter arteries, and embolization of a larger vascular bed was accomplished. The NBCA/Lip mixture with a low density of NBCA was located more peripherally from the catheter tip, and embolization of more peripheral and smaller diameter arteries was achieved.
CONCLUSIONS: The relationships of properties of NBCA/Lip in vitro and embolization effects in vivo of various ratios of NBCA/Lip were quantitatively examined and compared. The results of this study are useful for safe and effective embolization.
Authors:
Chiaki Takasawa; Kazumasa Seiji; Kenichi Matsunaga; Toshio Matsuhashi; Makoto Ohta; Shuya Shida; Kei Takase; Shoki Takahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  23     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1215-1221.e1     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.
Affiliation:
Departments of Diagnostic Radiology, Tohoku University, 2-1-1 Katahira Aoba-ku Sendai, 980-8577, Japan.
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