Document Detail


Properties of Flicker ERGs in Rat Models with Retinal Degeneration.
MedLine Citation:
PMID:  24555124     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Purpose. To describe the characteristics of rod and cone functions in rat models for congenital stationary night blindness (CSNB) and retinal cone dysfunction (RCD). Methods. Rod and cone function were isolated by recording the rod-/cone-driven flicker and blue light flicker electroretinograms (ERGs). Results. During dark adaptation, the amplitudes of flicker ERGs in CSNB rats were lower than those in control rats; the responses of RCD rats were similar to control rats. During light adaptation, the amplitudes of flicker ERGs in CSNB rats were reduced; whereas the responses of RCD rats were not detected. Blue flicker ERGs were not observed in CSNB rats at lower frequencies. The cone driven critical flicker frequencies (CFFs) in control rats were 62 Hz. The rod driven CFF of RCD rats was 20 Hz; whereas the rod-/cone-driven CFF of CSNB rats both were about 25 Hz. Conclusions. The function of the rod system was damaged completely, the cones were the source of vision in CSNB rats. Rod system function is excellent in RCD rat. The rods of albinism rats are sensitive to frequencies less than 20 Hz; whereas the cones are sensitive to frequencies up to 62 Hz.
Authors:
Jing An; Qun Guo; Li Li; Zuoming Zhang
Related Documents :
24466174 - Human placenta-derived adherent cell treatment of experimental stroke promotes function...
23485804 - How olfaction disorders can cause depression? the role of habenular degeneration.
24636504 - 17β estradiol increases resilience and improves hippocampal synaptic function in helple...
24839994 - Characterization of gastrointestinal absorption of digoxin involving influx and efflux ...
13794094 - Fine stuctural alterations in cell particles during chemical carcinogenesis. ii. furthe...
6595194 - Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the inf...
Publication Detail:
Type:  Journal Article     Date:  2012-05-22
Journal Detail:
Title:  ISRN ophthalmology     Volume:  2012     ISSN:  2090-5688     ISO Abbreviation:  ISRN Ophthalmol     Publication Date:  2012  
Date Detail:
Created Date:  2014-02-20     Completed Date:  2014-02-20     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  101585367     Medline TA:  ISRN Ophthalmol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  346297     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Near visual acuity following hyperopic photorefractive keratectomy in a presbyopic age group.
Next Document:  Histological and clinical features of primary and recurrent periocular Basal cell carcinoma.