Document Detail

Propensity of ectopic liver to hepatocarcinogenesis: case reports and a review of the literature.
MedLine Citation:
PMID:  9862850     Owner:  NLM     Status:  MEDLINE    
Two patients with ectopic liver are described. In one patient, a small ectopic liver attached to the gastric serosa developed hepatocellular carcinoma (HCC). The preoperative diagnosis was an alpha-fetoprotein (AFP)-producing carcinoma and a malignant ulcer of the stomach. Total gastrectomy and esophago-jejunostomy were performed. The tumor that measured 4 x 2 x 2 cm contained an AFP-producing HCC and normal liver tissue. In another patient who had alcoholic cirrhosis, ectopic liver on the serosa of the gallbladder was found to have the same histological changes as the mother liver. A survey of the literature disclosed more than 20 cases in which HCC developed outside the liver; the liver did not have HCC. By contrast, there was only one report on HCC occurring in the liver in the presence of a noncancerous, relatively large accessory liver lobe. Because ectopic liver does not have a complete vascular and ductal system as a normal liver, it is perhaps functionally handicapped and more prone to hepatocarcinogenesis.
M Arakawa; Y Kimura; K Sakata; Y Kubo; T Fukushima; K Okuda
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  29     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-03     Completed Date:  1999-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Department of Pathology, Ohmuta Municipal Hospital, Ohmuta, Japan.
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MeSH Terms
Carcinoma, Hepatocellular / etiology,  pathology*,  secretion
Choristoma / complications,  pathology*
Gallbladder Diseases / complications,  pathology
Liver Cirrhosis, Alcoholic / complications,  pathology
Liver Function Tests
Liver Neoplasms / etiology,  pathology*,  secretion
Middle Aged
Stomach Diseases / complications,  pathology*
alpha-Fetoproteins / secretion
Reg. No./Substance:
Comment In:
Hepatology. 1999 Aug;30(2):585-6   [PMID:  10447388 ]

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