Document Detail


Propargyl Hydrazides: Synthesis and Conversion Into Pyrazoles Through Hydroamination.
MedLine Citation:
PMID:  23143924     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pyrazoles direct: Propargyl alcohols undergoes hydrazination when treated with p-tosyl hydrazide in the presence of catalytic amounts of either Sc(OTf)(3) or La(OTf)(3) (see scheme; Tf=trifluoromethanesulfonyl). Propargyl hydrazides are converted into either N-tosyl or N-H pyrazoles when treated with an acid or a base, respectively. The one-step acid-catalyzed hydrazination/cyclization of propargyl alcohols directly affords pyrazoles in high yields.
Authors:
Mitsuhiro Yoshimatsu; Katsuki Ohta; Nami Takahashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1521-3765     ISO Abbreviation:  Chemistry     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, Faculty of Education, Gifu University, Yanagido 1-1, Gifu 501-1193 (Japan), Fax: (+81) 58-293-2251. yoshimae@gifu-u.ac.jp.
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