Document Detail

Propantheline as an adjuvant to weight loss after vertical gastroplasty.
MedLine Citation:
PMID:  9730524     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Weight loss after gastroplasty surgery is sometimes unsatisfactory despite normal surgical anatomy and no evidence of deliberate dietary indiscretion. METHODS: Two morbidly obese female patients were treated with a modified Long vertical gastroplasty following failed attempts at weight loss using nonsurgical means. One of these (109 kg) complained of a lack of satiety soon after the surgery and her weight loss was unsatisfactory at 11 kg after 90 days. The other patient (128 kg) lost weight as expected but at 3 months leveled off her weight at 93 kg also with an associated loss of satiety. Both patients noted an increased capacity for food and ease of eating solids including red meat. Gastroscopy revealed normal gastric anatomy in both and the patients were prescribed oral propantheline. RESULTS: There was an immediate subjective improvement in satiety, a reduction in capacity for food and an increase in difficulty with eating some solids. There was a resumption of weight loss that has been sustained down to healthy weight range. CONCLUSION: In two patients with unsatisfactory weight loss after gastroplasty but no demonstrable surgical defect, adjuvant propantheline appeared to induce an excellent further weight loss.
A C Jamieson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obesity surgery     Volume:  7     ISSN:  0960-8923     ISO Abbreviation:  Obes Surg     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-09-24     Completed Date:  1998-09-24     Revised Date:  2007-12-05    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Body Mass Index
Chemotherapy, Adjuvant
Gastrointestinal Motility / drug effects,  physiology
Gastroplasty / methods*
Middle Aged
Muscarinic Antagonists / administration & dosage,  therapeutic use*
Obesity, Morbid / surgery
Patient Satisfaction
Propantheline / administration & dosage,  therapeutic use*
Satiety Response / drug effects,  physiology
Stomach / drug effects,  physiopathology
Weight Loss*
Reg. No./Substance:
0/Muscarinic Antagonists; 298-50-0/Propantheline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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