Document Detail

Propagation through electrically coupled cells. How a small SA node drives a large atrium.
MedLine Citation:
PMID:  3801575     Owner:  NLM     Status:  MEDLINE    
Each normal cardiac cycle is started by an action potential that is initiated in the sino-atrial (SA) node by automaticity of the SA nodal cells. This action potential then propagates from the SA node into the surrounding atrial cells. We have done numerical simulations of electrically coupled cells to understand how a small SA node can be spontaneously active and yet be sufficiently electrically coupled to the surrounding quiescent atrial cells to initiate an action potential in the atrial cells. Our results with a simple model of two coupled cells and a more complex model of a two-dimensional sheet of cells suggest that some degree of electrical uncoupling of the cells within the SA node may be an essential design feature of the normal SA-atrial system.
R W Joyner; F J van Capelle
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biophysical journal     Volume:  50     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-03-20     Completed Date:  1987-03-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1157-64     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Atrial Function*
Cell Communication
Electric Conductivity
Models, Biological
Models, Neurological
Sinoatrial Node / physiology*
Grant Support

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