Document Detail


Propagation and electrical impedance changes due to ischemia, hypoxia and reperfusion in mouse hearts.
MedLine Citation:
PMID:  17946904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study is to quantitatively characterize major electrical markers of cardiac ischemia in normal mouse hearts to establish a set of baseline parameters for evaluation of genetically altered mouse hearts. Optical and electrical imaging techniques were coupled with impedance measurements to quantify changes induced by global ischemia. Optical and electrical mapping studies revealed the time course of conduction slowing and local inactivation during 30 minutes of ischemia or hypoxia. Measures of myocardial electrical impedance (MEI) were made during 30 and 120 minutes of global ischemia and proved to be qualitatively similar yet quantitatively distinct when compared to results reported from other mammals. The results of this study can now be applied in the analysis of genetically altered mouse hearts that are currently becoming available to help us understand cardiac death in disease.
Authors:
Qiansheng Liang; Kwanghyun Sohn; Bonnie B Punske
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference     Volume:  1     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2006  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1560-3     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, University of Utah, Salt Lake City, UT 84112-5000, USA. liang@cvrti.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Surface Potential Mapping / methods*
Electric Impedance
Heart Conduction System / pathology,  physiopathology*
Male
Mice
Mice, Inbred C57BL
Models, Cardiovascular
Myocardial Ischemia / diagnosis,  physiopathology*
Myocardial Reperfusion Injury / diagnosis,  physiopathology
Plethysmography, Impedance / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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