| Prooxidant-antioxidant balance in stroke patients and 6-month prognosis. | |
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MedLine Citation:
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PMID: 21500725 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Oxidative stress is thought to play an important role in the pathogenesis of stroke. METHODS: In the present study, we assessed the extent of oxidative stress in the sera of 120 patients in the first 24 hours after the onset of stroke and 80 healthy control subjects using a novel assay of prooxidant-antioxidant balance (PAB) that can measure the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby giving a redox index. RESULTS: In stroke patients median serum PAB values were significantly higher than that of the control group [125.50 (103.36 - 151.80) vs 43.40 (29.77 - 77.01), p < 0.001]. However, no significant difference was observed between subgroups of patients with transient ischemic attack (TIA), cerebral infarction or cerebral hemorrhage (p > 0.05). Median Serum PAB values were not significantly different in patients with different outcomes based on their 6-month prognosis (p > 0.05). CONCLUSIONS: We conclude that serum PAB values are elevated in patients with stroke, indicating a heightened state of oxidative stress, but do not distinguish between stroke types or predict 6-month prognosis. |
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Authors:
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Mohammad Reza Parizadeh; Mahmoud Reza Azarpazhooh; Naser Mobarra; Mohsen Nematy; Dariush Hamidi Alamdari; Shima Tavalaie; Amirhossein Sahebkar; Bahareh Hassankhani; Gordon Ferns; Majid Ghayour-Mobarhan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical laboratory Volume: 57 ISSN: 1433-6510 ISO Abbreviation: Clin. Lab. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705611 Medline TA: Clin Lab Country: Germany |
Other Details:
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Languages: eng Pagination: 183-91 Citation Subset: IM |
Affiliation:
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Biochemistry and Nutrition Research Center & Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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