| Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation. | |
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MedLine Citation:
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PMID: 20629489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women. STUDY DESIGN: A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 microg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study. RESULTS: Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group). CONCLUSION: Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy. |
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Authors:
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Fatemeh Tara; Margaret P Rayman; Hassan Boskabadi; Majid Ghayour-Mobarhan; Amirhossein Sahebkar; Daryoush H Alamdari; Behjat S Razavi; Shima Tavallaie; Mohsen Azimi-Nezhad; Mohammad T Shakeri; Mohammadreza Oladi; Omid Yazarlu; Shaida Ouladan; Maryam Teimoori Sangani; Fatemeh Rezagholizadeh Omran; Gordon Ferns |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 38 ISSN: 1619-3997 ISO Abbreviation: J Perinat Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 473-8 Citation Subset: IM |
Affiliation:
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Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antioxidants / metabolism Double-Blind Method Female Humans Infant, Newborn Male Oxidants / blood Oxidation-Reduction Oxidative Stress / drug effects Pregnancy Pregnancy Outcome Selenium / administration & dosage*, blood* Trace Elements / administration & dosage*, blood* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Oxidants; 0/Trace Elements; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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