Document Detail


Prooxidant-antioxidant balance and antioxidized LDL antibody level values and cardiac function in patients with coronary artery disease.
MedLine Citation:
PMID:  22854352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD).
METHODS: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients.
RESULTS: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05).
CONCLUSION: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
Authors:
Amir Ali Rahsepar; Asadollah Mirzaee; Fatemeh Moodi; Mohsen Moohebati; Shima Tavallaie; Ali Eshraghi; Maryam-Sadat Alavi; Fatemeh Khorashadizadeh; Hossein Pourghadamyari; Roghayeh Paydar; Maral Amini; Roshanak Khojasteh; Somayeh Mousavi; Maryam Sahebi; Majid Ghayour-Mobarhan; Gordon A A Ferns
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-31
Journal Detail:
Title:  Cardiology     Volume:  122     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-01-02     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / metabolism*
Antioxidants / metabolism*
Biological Markers / metabolism
Coronary Artery Disease / immunology,  physiopathology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G / metabolism*
Lipoproteins, LDL / immunology*
Male
Middle Aged
Oxidative Stress / immunology
Reactive Oxygen Species / metabolism
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antioxidants; 0/Biological Markers; 0/Immunoglobulin G; 0/Lipoproteins, LDL; 0/Reactive Oxygen Species; 0/oxidized low density lipoprotein
Comments/Corrections
Comment In:
Cardiology. 2014;127(1):70   [PMID:  24247700 ]
Cardiology. 2014;127(1):71-2   [PMID:  24247738 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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