| Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease. | |
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MedLine Citation:
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PMID: 22854352 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB. |
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Authors:
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Amir Ali Rahsepar; Asadollah Mirzaee; Fatemeh Moodi; Mohsen Moohebati; Shima Tavallaie; Ali Eshraghi; Maryam-Sadat Alavi; Fatemeh Khorashadizadeh; Hossein Pourghadamyari; Roghayeh Paydar; Maral Amini; Roshanak Khojasteh; Somayeh Mousavi; Maryam Sahebi; Majid Ghayour-Mobarhan; Gordon A A Ferns |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-31 |
Journal Detail:
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Title: Cardiology Volume: 122 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: - |
Other Details:
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Languages: ENG Pagination: 203-209 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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