Document Detail

'Proopiocortin fragments' in normal human adult pituitary. Distribution and ultrastructural characterization of immunoreactive cells.
MedLine Citation:
PMID:  6257006     Owner:  NLM     Status:  MEDLINE    
The distribution and ultrastructure of cells immunoreactive towards antisera against synthetic fragments of proopiocortin were studied in human pituitaries by immunohistochemical methods. Anterior lobe cells exhibiting the ultrastructural characteristics of corticolipotropes, as well as all epithelial cells 'invading' the posterior lobe, display beta-endorphin/beta-lipotropin-ACTH immunoreactivities. At low dilution a beta-lipotropin antiserum, raised with highly purified antigen, stains also somatotropes. alpha-MSH antibodies bind to certain corticolipotropic cells in the pars distalis and to only a few of the cells 'invading' the pars nervosa. Met-enkephalin antisera react only with isolated cells in the anterior lobe. These results indicate a striking difference in the processing of the proopiocortin precursor molecule in different corticolipotropic cells of the human hypophysis. Furthermore, the hypothesis of a homology between cells 'invading' the human neurohypophysis and those of the intermediate lobe of lower vertebrates, is questioned.
M R Celio; A Pasi; E Bürgisser; G Buetti; V Höllt; C Gramsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  95     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  27-40     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / immunology,  metabolism
Endorphins / immunology,  metabolism
Enkephalins / immunology,  metabolism
Fluorescent Antibody Technique
Immune Sera
Immunologic Techniques
Melanocyte-Stimulating Hormones / immunology
Middle Aged
Peptide Fragments / immunology*
Pituitary Gland / immunology,  metabolism,  ultrastructure*
Pituitary Hormones / immunology*
beta-Lipotropin / immunology,  metabolism
Reg. No./Substance:
0/Endorphins; 0/Enkephalins; 0/Immune Sera; 0/Peptide Fragments; 0/Pituitary Hormones; 0/proopiocortin fragments; 66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones; 9035-55-6/beta-Lipotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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