| Proof-of-Concept Study of Monitoring Cancer Drug Therapy with Cerenkov Luminescence Imaging. | |
| | |
MedLine Citation:
|
PMID: 22241909 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cerenkov luminescence imaging (CLI) has emerged as a less expensive, easier-to-use, and higher-throughput alternative to other nuclear imaging modalities such as PET. It is expected that CLI will find many applications in biomedical research such as cancer detection, probe development, drug screening, and therapy monitoring. In this study, we explored the possibility of using CLI to monitor drug efficacy by comparisons against PET. To assess the performance of both modalities in therapy monitoring, 2 murine tumor models (large cell lung cancer cell line H460 and prostate cancer cell line PC3) were given bevacizumab versus vehicle treatments. Two common radiotracers, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) and (18)F-FDG, were used to monitor bevacizumab treatment efficacy. METHODS: One group of mice (n = 6) was implanted with H460 xenografts bilaterally in the shoulder region, divided into treatment and control groups (n = 3 each), injected with (18)F-FLT, and imaged with PET immediately followed by CLI. The other group of mice (n = 6) was implanted with PC3 xenografts in the same locations, divided into treatment and control groups (n = 3 each), injected with (18)F-FDG, and imaged by the same modalities. Bevacizumab treatment was performed by 2 injections of 20 mg/kg at days 0 and 2. RESULTS: On (18)F-FLT scans, both CLI and PET revealed significantly decreased signals from H460 xenografts in treated mice from pretreatment to day 3. Moderately increased to unchanged signals were observed in untreated mice. On (18)F-FDG scans, both CLI and PET showed relatively unchanged signals from PC3 tumors in both treated and control groups. Quantifications of tumor signals of Cerenkov luminescence and PET images showed that the 2 modalities had excellent correlations (R(2) > 0.88 across all study groups). CONCLUSION: CLI and PET exhibit excellent correlations across different tumor xenografts and radiotracers. This is the first study, to our knowledge, demonstrating the use of CLI for monitoring cancer treatment. The findings warrant further exploration and optimization of CLI as an alternative to PET in preclinical therapeutic monitoring and drug screening. |
| | |
Authors:
|
Yingding Xu; Edwin Chang; Hongguang Liu; Han Jiang; Sanjiv Sam Gambhir; Zhen Cheng |
Related Documents
:
|
10664669 - The prostate: mr imaging and spectroscopy. present and future. 17949319 - Routine use of magnetic resonance imaging in the management of t(1c) carcinoma of the p... 17236979 - Effect of anatomic motion on proton therapy dose distributions in prostate cancer treat... 15752909 - Inverse treatment planning based on mri for hdr prostate brachytherapy. 7972739 - Prostate carcinoma: assessment of diagnostic criteria for capsular penetration on endor... 11687679 - Localized prostate cancer: effect of hormone deprivation therapy measured by using comb... 17504879 - Partial-volume effect in pet tumor imaging. 3406409 - Central pontine myelinolysis and its imitators: mr findings. 20505029 - Central trigeminal involvement in multiple sclerosis using high-resolution mri at 3 t. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: - ISSN: 1535-5667 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical significance of blood pressure ratios in hypertensive crisis in children.
Next Document: Validation of an Automatic Dose Injection System for Ictal SPECT in Epilepsy.