Document Detail

Pronounced reduction of aortic flow velocity and acceleration during heavy isometric exercise in coronary artery disease.
MedLine Citation:
PMID:  1872276     Owner:  NLM     Status:  MEDLINE    
Doppler-derived parameters of aortic flow were examined during heavy isometric exercise in 48 men with coronary artery disease (CAD) and in 48 gender- and age-matched healthy controls. The aim was to determine which parameters best separated the groups and to look for a possible relation between exercise-induced Doppler patterns and the extent of CAD. Isometric exercise was performed with a 2-hand bar dynamometer, and the subjects were required to perform 50% of maximal voluntary contraction for 2 minutes. Examination was performed with a pulsed Doppler transducer positioned at the suprasternal notch. Resting peak flow velocity, acceleration time, stroke volume index and cardiac index did not show significant differences between the groups. However, mean acceleration and stroke work were significantly lower in patients with CAD. In this group, exercise peak flow velocity decreased from 98 +/- 13 to 55 +/- 12 cm/s, flow velocity integral from 14 +/- 3 to 7 +/- 3 cm, mean acceleration from 11 +/- 0.9 to 4.7 +/- 1 m/s/s, and stroke volume index from 41 +/- 6 to 23 +/- 4 ml/m2 (p less than 0.001 for all). Cardiac index decreased from 2.7 +/- 0.4 to 2 +/- 0.2 liters/min/m2 (p less than 0.05). Acceleration time increased from 82 +/- 6 to 116 +/- 7 ms. In most of the indexes, the directional changes induced by isometric exercise were similar in patients with CAD and in normal control subjects. The differences compared with the rest values were significantly greater in the CAD group, and especially in patients presenting with 3-vessel disease.(ABSTRACT TRUNCATED AT 250 WORDS)
E Z Fisman; E Ben-Ari; A Pines; Y Drory; R J Shiner; M Motro; J J Kellermann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  68     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-13     Completed Date:  1991-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  AIM; IM    
Cardiac Rehabilitation Institute, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Aorta / physiopathology*,  ultrasonography
Blood Flow Velocity / physiology
Blood Pressure / physiology
Coronary Angiography
Coronary Disease / physiopathology*,  radiography,  ultrasonography
Echocardiography, Doppler
Heart Rate / physiology
Isometric Contraction / physiology*
Middle Aged
Reference Values
Reproducibility of Results
Stroke Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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