Document Detail

Prompt relief of vasospastic angina by calcium antagonists.
MedLine Citation:
PMID:  3108169     Owner:  NLM     Status:  MEDLINE    
A 57-year-old man had recurrent episodes of angina pectoris at rest. An electrocardiogram (ECG) during attack revealed transient ST elevations in leads V1 to V5. His symptoms were not relieved by sublingual nitroglycerin (TNG), but subsided promptly following sublingual or intravenous calcium antagonists. However, there was no difference between the degree of ST elevation on ECG recorded during the treatment of angina with either TNG or with calcium antagonist. Recurrent angina and painless ST elevation on Holter ECG recordings were prevented by a large dose of diltiazem. Coronary arteriography revealed only mild stenosis at the proximal portion of the left anterior descending coronary artery. It is suggested that coronary artery spasm was the cause of angina in this case and that sublingual or intravenous calcium antagonist was more effective in the treatment of acute attack of vasospastic angina than sublingual TNG.
K Egashira; H Araki; H Tomoike; A Takeshita; M Nakamura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  25     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-08     Completed Date:  1987-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  175-7     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris, Variant / drug therapy*,  physiopathology
Calcium Channel Blockers / therapeutic use*
Diltiazem / therapeutic use
Middle Aged
Nitroglycerin / therapeutic use
Reg. No./Substance:
0/Calcium Channel Blockers; 42399-41-7/Diltiazem; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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