Document Detail

Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects.
MedLine Citation:
PMID:  22863748     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to determine whether acute exercise load alters serum retinol-binding protein 4 (RBP4) and numbers of endothelial progenitor cells (EPC) in diabetic subjects. Sixty-two subjects with type 2 diabetes mellitus were enrolled in the present study. They were 50 males and 12 females with the ages of 65.1±8.1 (mean ± SD) years. Cardio-pulmonary exercise stress test (CPX) was carried out, and the numbers of EPC and serum RBP4 levels before and after the CPX were measured. RBP4 is a cytokine synthesized in hepatocytes, white adipose tissues and skeletal muscles, and serum RBP4 was determined by ELISA. EPC was determined as CD34(+)/133(+) cells by FACS. The subjects were subgrouped into two groups with or without nephropathy. Serum RBP4 levels promptly increased from 48.2±4.3 (mean±SEM) to 54.3±4.2 μg/mL after the CPX (mean exercise time of 8 min) in the diabetic subjects without nephropathy (p=0.0006), but did not in those with nephropathy. There was a positive correlation between changes in serum RBP4 during the exercise and estimated glomerular filtration rate (r=0.30, p=0.018). Also, an acute exercise load promptly increased the number of EPCs in the diabetic subjects with and without nephropathy. These findings suggest that a prompt increase in exercise-induced RBP4 is retarded by progression of nephropathy, and that an exercise-induced mobilization of EPCs could maintain endothelial cells in diabetic subjects.
Atsushi Aoki; Miho Murata; Tomoko Asano; Aki Ikoma; Masami Sasaki; Tomoyuki Saito; Taeko Otani; Sachimi Jinbo; Nahoko Ikeda; Masanobu Kawakami; San-E Ishikawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  Endocrine journal     Volume:  59     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-05     Revised Date:  2014-11-10    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1085-91     Citation Subset:  IM    
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MeSH Terms
Cell Count
Diabetes Mellitus, Type 2 / blood,  complications,  metabolism*,  pathology*
Diabetic Nephropathies / blood,  metabolism
Disease Progression
Endothelial Cells / pathology*,  physiology
Exercise / physiology*
Exercise Test
Middle Aged
Retinol-Binding Proteins, Plasma / metabolism*
Stem Cells / pathology,  physiology
Reg. No./Substance:
0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma

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