| Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects. | |
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MedLine Citation:
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PMID: 22863748 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study was undertaken to determine whether acute exercise load alters serum retinol-binding protein 4 (RBP4) and numbers of endothelial progenitor cells (EPC) in diabetic subjects. Sixty-two subjects with type 2 diabetes mellitus were enrolled in the present study. They were 50 males and 12 females with the ages of 65.1±8.1 (mean ± SD) years. Cardio-pulmonary exercise stress test (CPX) was carried out, and the numbers of EPC and serum RBP4 levels before and after the CPX were measured. RBP4 is a cytokine synthesized in hepatocytes, white adipose tissues and skeletal muscles, and serum RBP4 was determined by ELISA. EPC was determined as CD34<sup>+</sup>/133<sup>+</sup> cells by FACS. The subjects were subgrouped into two groups with or without nephropathy. Serum RBP4 levels promptly increased from 48.2±4.3 (mean±SEM) to 54.3±4.2 µg/ml after the CPX (mean exercise time of 8 min) in the diabetic subjects without nephropathy (p=0.0006), but did not in those with nephropathy. There was a positive correlation between changes in serum RBP4 during the exercise and estimated glomerular filtration rate (r=0.30, p=0.018). Also, an acute exercise load promptly increased the number of EPCs in the diabetic subjects with and without nephropathy. These findings suggest that a prompt increase in exercise-induced RBP4 is retarded by progression of nephropathy, and that an exercise-induced mobilization of EPCs could maintain endothelial cells in diabetic subjects. |
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Authors:
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Atsushi Aoki; Miho Murata; Tomoko Asano; Aki Ikoma; Masami Sasaki; Tomoyuki Saito; Taeko Otani; Sachimi Jinbo; Nahoko Ikeda; Masanobu Kawakami; San-E Ishikawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-03 |
Journal Detail:
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Title: Endocrine journal Volume: - ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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