Document Detail


Prompt elevations of PGE2 and thromboxane A2 metabolites in peripheral node efferent lymph of sheep following drainage area immunization.
MedLine Citation:
PMID:  2722480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the past decade, the main interest in the involvement of prostaglandin E2 (PGE2) in the immune response has been concerned with its role in immunomodulation (suppression) both in vitro and in vivo. Comparatively little attention has been devoted to its immunostimulatory role. It has been suggested that PGE2, like histamine, may function as a 'double agent', initially triggering, facilitating and augmenting a stimulatory immune response and later modulating, limiting and contributing to the turning off of this response. We here report an early (within minutes) immunostimulatory involvement of PGE2 (and thromboxane A2) in the sheep, with prompt elevations in levels of PGE2 and thromboxane B2 in popliteal lymph node efferent lymph following drainage area immunization with killed Salmonella muenchen bacteria. These elevations were associated with an increase in efferent lymph flow and an equally prompt but limited depression of lymphocyte outputs into efferent lymph ('shutdown', 'recruitment'). Local increases in blood flow and vascular permeability probably play important roles in these events.
Authors:
T C Moore; C H Spruck; J L Lami; S I Said
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunopharmacology     Volume:  17     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:    1989 Mar-Apr
Date Detail:
Created Date:  1989-06-30     Completed Date:  1989-06-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Affiliation:
Department of Surgery, UCLA School of Medicine.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Drainage
Immunization*
Lymph / analysis
Lymph Nodes / metabolism*
Lymphocytes / metabolism
Prostaglandins E / metabolism*
Salmonella / immunology
Sheep
Thromboxane A2 / metabolism*
Thromboxane B2 / biosynthesis
Time Factors
Grant Support
ID/Acronym/Agency:
DK AI-37895/DK/NIDDK NIH HHS; HL-30450/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins E; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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