Document Detail


Prompt Bone Marrow-Derived Mesenchymal Stem Cell Therapy Enables Early Porcine Heart Function Recovery from Acute Myocardial Infarction.
MedLine Citation:
PMID:  24965596     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Impact of early bone marrow-derived mesenchymal stem cell (BMDMSC) implantation on left ventricular (LV) function after AMI was studied.Twelve mini-pigs were equally divided into placebo (AMI through left coronary artery ligation) and cell-treated groups [BMDMSCs (3.0 × 10(7)) implanted into infarct area (IA)] with myocardium harvested by post-AMI day 90. Six healthy animals served as controls.On post-AMI day 90, magnetic resonance imaging showed a lower LV ejection fraction but higher LV dimensions in the placebo group (P < 0.003) that also had increased IAs but reduced wall thickness (P < 0.005). Pro-apoptotic gene expressions (Bax, caspase-3) and apoptotic nucleus number in IAs and peri-IAs were highest in the placebo group (P < 0.001). Inflammatory biomarker expressions (MMP-9, oxidized protein, CD40+ cells) were highest, whereas those of angiogenesis (VEGF, CD31+ cells, SDF-1α, CXCR4) and myocardium-preservation (connexin43, troponin-I, cytochrome-C) were lowest in the placebo group (P < 0.01).BMDMSC implantation preserved LV function and alleviated remodeling at post-AMI day 90.
Authors:
Chang-Qing Fan; Steve Leu; Jiunn-Jye Sheu; Yen-Yi Zhen; Tzu-Hsien Tsai; Yung-Lung Chen; Sheng-Ying Chung; Han-Tan Chai; Cheuk-Kwan Sun; Jenq-Lin Yang; Hsueh-Wen Chang; Sheung-Fat Ko; Hon-Kan Yip
Related Documents :
24909956 - Expression of dual nucleotides/cysteinyl-leukotrienes receptor gpr17 in early trafficki...
8261476 - Reversible catecholamine-induced cardiomyopathy presenting as acute pulmonary edema in ...
3731896 - Malignant lymphoma of the heart in acquired immune deficiency syndrome.
10171636 - Pitfalls in the echocardiographic diagnosis of intracardiac and extracardiac masses.
23996806 - Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an ob...
10099926 - An echocardiographic study of right and left ventricular adaptation to physical exercis...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-25
Journal Detail:
Title:  International heart journal     Volume:  -     ISSN:  1349-3299     ISO Abbreviation:  Int Heart J     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Further observations on associations between the ADA gene and past malaria morbidity in Sardinia.
Next Document:  Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders.