Document Detail


Promotion and regression of atherosclerosis in vervet monkeys by diets realistic for westernized people.
MedLine Citation:
PMID:  3632759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have described and measured aortic and arterial atherosclerosis in adult female Vervet monkeys (n = 61) after application of dietary treatments for 47 months. The diets were compounded entirely of normal food items for westernized people, with no extra cholesterol added. A 'Western' diet (WD), known to induce hypercholesterolaemia, was found to be atherogenic in aortas and some arteries. A more 'prudent' diet (PD) induced much less lipid infiltration into aortic intimas and was not associated with serious atherosclerotic changes. However, when this PD was used as a treatment for 27 months, following 20 months of nutrition by the WD, minimal regression of cholesterol crystals and non-lipid components of atherosclerotic plaque was detected. There was no significant coronary artery or myocardial disease in these adult females after 47 months of feeding on the WD whereas males do develop coronary atherosclerosis and myocardial fibrosis. For this model the PD would be more effective in preventing atherosclerosis than treating advanced lesions. We believe this is the first time that the pathology of atherosclerosis promoted by realistic diets has been modelled in adult females of this species.
Authors:
J E Fincham; C W Woodroof; M J van Wyk; D Capatos; M J Weight; D Kritchevsky; J E Rossouw
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  66     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-10-16     Completed Date:  1987-10-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena
Animals
Aorta / pathology
Arteriosclerosis / etiology*,  pathology
Cercopithecus / metabolism*
Cercopithecus aethiops / metabolism*
Diet, Atherogenic*
Female
Hypercholesterolemia / etiology*
Time Factors
Grant Support
ID/Acronym/Agency:
HL-00734/HL/NHLBI NIH HHS; HL-03299/HL/NHLBI NIH HHS; HL-05209/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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