Document Detail


Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice.
MedLine Citation:
PMID:  9097974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatic tumor promoting activity was determined for mixtures of dichloroacetic acid (DCA) and trichloroacetic acid (TCA) in female B6C3F1 mice initiated on day 15 of age with 25 mg/kg N-methyl-N-nitrosourea. The mice received in their drinking water from 6 to 50 weeks of age either DCA (7.8, 15.6, or 25 mmol/l) with/without 6.0 mmol/l TCA or TCA (6.0 or 25 mmol/l) with/without 15.6 mmol/l DCA. Proliferative lesions (foci of altered hepatocytes and hepatocellular adenomas) promoted by TCA increased linearly with its concentration and were predominantly basophilic and negative for glutathione S-transferase-pi (GST-pi), while those promoted by DCA increased exponentially with its concentration and were eosinophilic and positive for GST-pi. The promoting activity of DCA and TCA in mixtures was at least additive. The proliferative lesions resulting from exposure to the mixtures were predominately similar to those promoted by DCA, i.e. contained eosinophilic and GST-pi-positive hepatocytes.
Authors:
M A Pereira; K Li; P M Kramer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  115     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Affiliation:
Medical College of Ohio, Department of Pathology, Toledo 43614, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Carcinogens / pharmacology*
Cocarcinogenesis*
Dichloroacetate / administration & dosage,  toxicity*
Drug Combinations
Female
Glutathione Transferase / analysis
Immunohistochemistry
Liver / pathology
Liver Neoplasms, Experimental / chemically induced*,  enzymology,  pathology
Methylnitrosourea*
Mice
Organ Size
Time Factors
Trichloroacetic Acid / administration & dosage,  toxicity*
Water Pollutants, Chemical
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Drug Combinations; 0/Water Pollutants, Chemical; 13425-80-4/Dichloroacetate; 684-93-5/Methylnitrosourea; 76-03-9/Trichloroacetic Acid; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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