| Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. | |
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MedLine Citation:
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PMID: 9097974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatic tumor promoting activity was determined for mixtures of dichloroacetic acid (DCA) and trichloroacetic acid (TCA) in female B6C3F1 mice initiated on day 15 of age with 25 mg/kg N-methyl-N-nitrosourea. The mice received in their drinking water from 6 to 50 weeks of age either DCA (7.8, 15.6, or 25 mmol/l) with/without 6.0 mmol/l TCA or TCA (6.0 or 25 mmol/l) with/without 15.6 mmol/l DCA. Proliferative lesions (foci of altered hepatocytes and hepatocellular adenomas) promoted by TCA increased linearly with its concentration and were predominantly basophilic and negative for glutathione S-transferase-pi (GST-pi), while those promoted by DCA increased exponentially with its concentration and were eosinophilic and positive for GST-pi. The promoting activity of DCA and TCA in mixtures was at least additive. The proliferative lesions resulting from exposure to the mixtures were predominately similar to those promoted by DCA, i.e. contained eosinophilic and GST-pi-positive hepatocytes. |
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Authors:
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M A Pereira; K Li; P M Kramer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 115 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-04-29 Completed Date: 1997-04-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 15-23 Citation Subset: IM |
Affiliation:
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Medical College of Ohio, Department of Pathology, Toledo 43614, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Carcinogens / pharmacology* Cocarcinogenesis* Dichloroacetate / administration & dosage, toxicity* Drug Combinations Female Glutathione Transferase / analysis Immunohistochemistry Liver / pathology Liver Neoplasms, Experimental / chemically induced*, enzymology, pathology Methylnitrosourea* Mice Organ Size Time Factors Trichloroacetic Acid / administration & dosage, toxicity* Water Pollutants, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Drug Combinations; 0/Water Pollutants, Chemical; 13425-80-4/Dichloroacetate; 684-93-5/Methylnitrosourea; 76-03-9/Trichloroacetic Acid; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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