| Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats. | |
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MedLine Citation:
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PMID: 6642136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of sodium o-phenylphenate (OPP-Na) and o-phenylphenol (OPP) on 2-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at levels of 0.01 or 0.05% in drinking water were investigated. Administration of 2.0% OPP-Na in the diet significantly increased both the incidence and the number per 10 cm of basement membrane of preneoplastic lesions (papillary or nodular hyperplasia; PN hyperplasia) of the urinary bladder in rats pretreated with 0.01% BBN, and also those of papilloma and cancer of the urinary bladder in the group pretreated with 0.05% BBN. Moreover, treatment with 2.0% OPP-Na, without prior BBN initiation, induced PN hyperplasia, papilloma and cancer. In contrast, OPP appeared to produce only a slight increase in the incidence of urinary bladder lesions following BBN, and its effect was not statistically significant. It also did not induce tumors of the urinary bladder. These results provide evidence that OPP-Na has promoting activity toward the urinary bladder while OPP does not. Moreover, the possibility that OPP-Na may be a complete carcinogen in the rat urinary bladder deserves consideration. |
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Authors:
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S Fukushima; Y Kurata; M Shibata; E Ikawa; N Ito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gann = Gan Volume: 74 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1984-01-26 Completed Date: 1984-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 625-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biphenyl Compounds / toxicity* Body Weight / drug effects Butylhydroxybutylnitrosamine Carcinoma, Transitional Cell / chemically induced*, pathology Male Rats Rats, Inbred F344 Urinary Bladder Neoplasms / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 3817-11-6/Butylhydroxybutylnitrosamine; 90-43-7/2-phenylphenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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